Gene

apobb.1

ID

ZDB-GENE-030131-9732

Name

apolipoprotein Bb, tandem duplicate 1

Symbol

apobb.1 Nomenclature History

Previous Names

apobb
apobl (1)
cb235 (1)
hm:zeh1207
sb:cb235
si:ch211-219i10.1
wu:fb39c11
wu:fc51e12
zeh1207

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have lipid transporter activity. Involved in cellular response to xenobiotic stimulus. Is expressed in intestine; liver; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); biliary tract cancer (multiple); familial hyperlipidemia (multiple); hypobetalipoproteinemia (multiple); and sickle cell anemia. Orthologous to human APOB (apolipoprotein B).

Genome Resources

Note

None

Expression

All Expression Data

19 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

Wild Type Expression Summary

Phenotype

All Phenotype Data: Fig. 7 from Seth et al., 2010
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With apobb.1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
familial hypobetalipoproteinemia 1	Alliance	Hypobetalipoproteinemia	615558
		Hypercholesterolemia, familial, 2	144010

Associated With apobb.1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001747	Lipid transport protein, N-terminal
Domain	IPR009454	Lipid transport, open beta-sheet
Domain	IPR015255	Vitellinogen, open beta-sheet
Homologous_superfamily	IPR011030	Lipovitellin-phosvitin complex, superhelical domain
Homologous_superfamily	IPR015816	Vitellinogen, beta-sheet N-terminal
Homologous_superfamily	IPR015819	Lipid transport protein, beta-sheet shell
Homologous_superfamily	IPR016024	Armadillo-type fold