ZFIN Gene: apobb.1

ZFIN ID: ZDB-GENE-030131-9732

ZFIN ID: ZDB-GENE-030131-9732

Gene Name:

apolipoprotein Bb, tandem duplicate 1

Gene Symbol:

apobb.1 Nomenclature History

Previous Names:

apobb, apobl (1), cb235 (1), hm:zeh1207, sb:cb235, si:ch211-219i10.1, wu:fb39c11, wu:fc51e12, zeh1207

Gene Type:

protein_coding_gene

Location:

Chr: 20 Mapping Details/Browsers

Description:

Predicted to have lipid transporter activity. Involved in cellular response to xenobiotic stimulus. Is expressed in intestine; liver; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); biliary tract cancer (multiple); familial hyperlipidemia (multiple); hypobetalipoproteinemia (multiple); and sickle cell anemia. Orthologous to human APOB (apolipoprotein B).

Genome Resources:

Alliance (1), Gene:321166 (1), Ensembl(GRCz11):ENSDARG00000022767 (2)

GENE EXPRESSION
All Expression Data:	19 figures from 7 publications
Directly Submitted Expression Data:	6 figures (6 images) from Thisse et al., 2001 [cb235]
	6 figures (6 images) from Thisse et al., 2004 [IMAGE:7138028]
Wild-type Stages, Structures:	Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
	intestine liver unspecified whole organism yolk syncytial layer
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
c832Tg	Transgenic Insertion	Unknown	Unknown	DNA_AND_TALEN
sa6637	Point Mutation	Unknown	Premature Stop	ENU
sa6638	Point Mutation	Unknown	Premature Stop	ENU
sa10039	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa12118	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa16833	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa18137	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa32301	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa37070	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa37071	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa43475	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa43476	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-apobb.1	N/A	2
MO2-apobb.1	N/A	2
TALEN1-apobb.1	c832Tg	1

PHENOTYPE

Data:	Fig. 7 from Seth et al., 2010
Observed in:	optic chiasm optic stalk retinal ganglion cell whole organism

DISEASE ASSOCIATED WITH apobb.1 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
familial hypobetalipoproteinemia 1	Alliance	Hypobetalipoproteinemia	615558
		Hypercholesterolemia, familial, 2	144010

DISEASE ASSOCIATED WITH apobb.1 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	cellular response to xenobiotic stimulus (more)
Cellular Component	low-density lipoprotein particle (more)
Molecular Function	lipid transporter activity (more)

GO Terms (all 12)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	apobb.1-201 (1)	11495	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS

Addgene:PCRII apoBb.1

Addgene:pDONR_P4-P1R_5'arm_apobb.1

Addgene:pDONR_P2R-P3_3'arm_apobb.1

CONSTRUCTS WITH SEQUENCES FROM apobb.1 No data available

MARKER RELATIONSHIPS

apobb.1 Contained in:	[BAC] CH211-219I10 (1)
apobb.1 Encodes:	[EST] cb235 (1) (order this), fb39c11 (1), fc51e12 (1), IMAGE:7050742, IMAGE:7138028 (1), fb39e09 (1), zeh1207 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001030062 (1)	11495 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX511210 (1)	62936 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q5TZ29 (1)	3730 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 26)

ORTHOLOGY for apobb.1 ( Chr: 20 )

CITATIONS (50)

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