Gene
apobb.1
- ID
- ZDB-GENE-030131-9732
- Name
- apolipoprotein Bb, tandem duplicate 1
- Symbol
- apobb.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have cholesterol transfer activity and low-density lipoprotein particle receptor binding activity. Involved in cellular response to xenobiotic stimulus. Predicted to localize to low-density lipoprotein particle; mature chylomicron; and very-low-density lipoprotein particle. Is expressed in intestine; liver; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); biliary tract cancer (multiple); familial hyperlipidemia (multiple); hypobetalipoproteinemia (multiple); and sickle cell anemia. Orthologous to human APOB (apolipoprotein B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb235 (6 images)
- IMAGE:7138028 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Seth et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial hypobetalipoproteinemia 1 | Alliance | Hypobetalipoproteinemia | 615558 |
| Hypercholesterolemia, familial, 2 | 144010 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001747 | Lipid transport protein, N-terminal |
| Domain | IPR009454 | Lipid transport, open beta-sheet |
| Domain | IPR015255 | Vitellinogen, open beta-sheet |
| Homologous_superfamily | IPR011030 | Lipovitellin-phosvitin complex, superhelical domain |
| Homologous_superfamily | IPR015816 | Vitellinogen, beta-sheet N-terminal |
| Homologous_superfamily | IPR015819 | Lipid transport protein, beta-sheet shell |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
Domain Details Per Protein
| Protein | Length | Armadillo-type fold | Lipid transport, open beta-sheet | Lipid transport protein, beta-sheet shell | Lipid transport protein, N-terminal | Lipovitellin-phosvitin complex, superhelical domain | Vitellinogen, beta-sheet N-terminal | Vitellinogen, open beta-sheet |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A286YAF6
|
3643 | |||||||
|
UniProtKB:Q5TZ29
|
3730 | |||||||
|
UniProtKB:Q5BLC2
|
461 | |||||||
|
UniProtKB:A8E4Z5
|
419 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
apobb.1-201
(1)
|
11495 nt |
Interactions and Pathways
No data available
Plasmids