Gene

mcm4

ID
ZDB-GENE-030131-9544
Name
minichromosome maintenance complex component 4
Symbol
mcm4 Nomenclature History
Previous Names
  • cb1025 (1)
  • fc12c09
  • fj85g09
  • hm:zeh1616 (1)
  • wu:fc12c09 (1)
  • wu:fj85g09 (1)
  • zeh1616
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Exhibits chromatin binding activity. Involved in response to yeast. Predicted to localize to MCM complex and nucleus. Is expressed in digestive system; nervous system; otic vesicle; pectoral fin; and proliferative region. Human ortholog(s) of this gene implicated in immunodeficiency 54. Orthologous to human MCM4 (minichromosome maintenance complex component 4).
Genome Resources
Note
None
Expression
All Expression Data
21 figures from 5 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mcm4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency 54 Alliance Immunodeficiency 54 609981
Associated With mcm4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018525 Mini-chromosome maintenance, conserved site
Domain IPR001208 MCM domain
Domain IPR003593 AAA+ ATPase domain
Domain IPR027925 MCM N-terminal domain
Domain IPR033762 MCM OB domain
Domain IPR041562 MCM, AAA-lid domain
Family IPR008047 Mini-chromosome maintenance complex protein 4
Family IPR031327 Mini-chromosome maintenance protein
Homologous_superfamily IPR012340 Nucleic acid-binding, OB-fold
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length AAA+ ATPase domain MCM, AAA-lid domain MCM domain MCM N-terminal domain MCM OB domain Mini-chromosome maintenance complex protein 4 Mini-chromosome maintenance, conserved site Mini-chromosome maintenance protein Nucleic acid-binding, OB-fold P-loop containing nucleoside triphosphate hydrolase
UniProtKB:Q6NZV2 845
UniProtKB:Q6PHK9 750
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-mcm4 polyclonal Rabbit
  • WB
Bethyl Laboratories, Inc.
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations