ZFIN ID: ZDB-GENE-030131-9532
Gene Name: phospholipase C, gamma 2
Gene Symbol: plcg2
Sequence Ontology ID : SO:0000704

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Previous Names: fj85b03, sb:eu1064, si:ch211-260p9.2, wu:fj85b03, zgc:152893

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(Including Attributions)
Location: Chr: 18 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have phosphatidylinositol phospholipase C activity; predicted to be involved in release of sequestered calcium ion into cytosol; orthologous to human PLCG2 (phospholipase C gamma 2).
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu1064]
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa18057 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23252 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25057 Point Mutation Unknown Premature Stop ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH plcg2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    familial cold autoinflammatory syndrome 3 Familial cold autoinflammatory syndrome 3 614468
    Autoinflammation, antibody deficiency, and immune dysregulation syndrome 614878
    DISEASE ASSOCIATED WITH plcg2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process intracellular signal transduction (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000008 (1)
  • InterPro:IPR000909 (1)
  • InterPro:IPR000980 (1)
  • InterPro:IPR001192 (1)
  • InterPro:IPR001452 (1)
  • InterPro:IPR001711 (1)
  • InterPro:IPR001849 (1)
  • InterPro:IPR011992 (1)
  • InterPro:IPR011993 (1)
  • InterPro:IPR016279 (1)
  • InterPro:IPR017946 (1)
  • InterPro:IPR028381 (1)
  • InterPro:IPR035023 (1)
  • InterPro:IPR035024 (1)
  • InterPro:IPR035723 (1)
  • InterPro:IPR035892 (1)
  • InterPro:IPR036028 (1)
  • InterPro:IPR036860 (1)
  • PROSITE:PS50001 (1)
  • PROSITE:PS50002 (1)
  • PROSITE:PS50003 (1)
  • PROSITE:PS50004 (1)
  • PROSITE:PS50008 (1)
  • Pfam:PF00017 (1)
  • Pfam:PF00018 (1)
  • Pfam:PF00168 (1)
  • Pfam:PF00387 (1)
  • Pfam:PF00388 (1)
  • EC:3.1.4.11 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA plcg2-201 (1) 4296
    plcg2-202 (1) 500
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM plcg2 No data available
    MARKER RELATIONSHIPS
    plcg2Contained in: [BAC] CH211-260P9 (1) (order this)
    plcg2Encodes: [EST] eu1064 (1), fj85b03
    [cDNA] MGC:152893 (1), MGC:191757 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001044968 (1) 4296bp
    Genomic GenBank:BX511124 (1) 149227bp
    Select Tool
    Polypeptide UniProtKB:Q08BR5 (1) 1240aa
    Sequence Clusters UniGene:11512 (1)
    Sequence Information (all 20)
    OTHER plcg2 GENE PAGES
  • Alliance (1)
  • Gene:561747 (1)
  • VEGA:OTTDARG00000012465 (1)
  • Ensembl(GRCz11):ENSDARG00000068763 (2)
  • ORTHOLOGY for plcg2 (Chr: 18)
    CITATIONS (21)