Gene

plcg2

ID
ZDB-GENE-030131-9532
Name
phospholipase C, gamma 2
Symbol
plcg2 Nomenclature History
Previous Names
  • fj85b03
  • sb:eu1064
  • si:ch211-260p9.2
  • wu:fj85b03
  • zgc:152893
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have phosphatidylinositol phospholipase C activity. Predicted to be involved in several processes, including inositol trisphosphate biosynthetic process; phosphatidylinositol-mediated signaling; and release of sequestered calcium ion into cytosol. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 3. Orthologous to human PLCG2 (phospholipase C gamma 2).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With plcg2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial cold autoinflammatory syndrome 3 Alliance Familial cold autoinflammatory syndrome 3 614468
Autoinflammation, antibody deficiency, and immune dysregulation syndrome 614878
Associated With plcg2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000008 C2 domain
Domain IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
Domain IPR000980 SH2 domain
Domain IPR001452 SH3 domain
Domain IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
Domain IPR001849 Pleckstrin homology domain
Domain IPR035023 PLC-gamma, C-terminal SH2 domain
Domain IPR035024 PLC-gamma, N-terminal SH2 domain
Domain IPR035723 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain
Family IPR001192 Phosphoinositide phospholipase C family
Family IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
Family IPR028381 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Homologous_superfamily IPR011992 EF-hand domain pair
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Homologous_superfamily IPR035892 C2 domain superfamily
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain C2 domain C2 domain superfamily EF-hand domain pair PH-like domain superfamily Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma Phosphatidylinositol-specific phospholipase C, X domain Phosphoinositide phospholipase C family Phospholipase C, phosphatidylinositol-specific, Y domain PLC-gamma, C-terminal SH2 domain PLC-gamma, N-terminal SH2 domain PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily Pleckstrin homology domain SH2 domain SH2 domain superfamily SH3 domain SH3-like domain superfamily
UniProtKB:Q08BR5 1240
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations