Gene

plcg2

ID

ZDB-GENE-030131-9532

Name

phospholipase C, gamma 2

Symbol

plcg2 Nomenclature History

Previous Names

fj85b03
sb:eu1064
si:ch211-260p9.2
wu:fj85b03
zgc:152893

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have phosphatidylinositol phospholipase C activity. Predicted to be involved in several processes, including inositol trisphosphate biosynthetic process; phosphatidylinositol-mediated signaling; and release of sequestered calcium ion into cytosol. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 3. Orthologous to human PLCG2 (phospholipase C gamma 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2005

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu1064 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With plcg2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
familial cold autoinflammatory syndrome 3	Alliance	Familial cold autoinflammatory syndrome 3	614468
		Autoinflammation, antibody deficiency, and immune dysregulation syndrome	614878

Associated With plcg2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000008	C2 domain
Domain	IPR000909	Phosphatidylinositol-specific phospholipase C, X domain
Domain	IPR000980	SH2 domain
Domain	IPR001452	SH3 domain
Domain	IPR001711	Phospholipase C, phosphatidylinositol-specific, Y domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR035023	PLC-gamma, C-terminal SH2 domain
Domain	IPR035024	PLC-gamma, N-terminal SH2 domain
Domain	IPR035723	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain
Family	IPR001192	Phosphoinositide phospholipase C family
Family	IPR016279	Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
Homologous_superfamily	IPR011992	EF-hand domain pair
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR017946	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036860	SH2 domain superfamily

Domain Details Per Protein

Protein	Length	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain	C2 domain	C2 domain superfamily	EF-hand domain pair	PH-like domain superfamily	Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma	Phosphatidylinositol-specific phospholipase C, X domain	Phosphoinositide phospholipase C family	Phospholipase C, phosphatidylinositol-specific, Y domain	PLC-gamma, C-terminal SH2 domain	PLC-gamma, N-terminal SH2 domain	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily	Pleckstrin homology domain	SH2 domain	SH2 domain superfamily	SH3 domain	SH3-like domain superfamily
UniProtKB:Q1LWV8 InterPro	1240

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	plcg2-201 (1) Ensembl	Havana	4296 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	plcg2-202 (1) Ensembl	Havana	500 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations