ZFIN ID: ZDB-GENE-030131-9532
Gene Name: phospholipase C, gamma 2
Gene Symbol: plcg2    Nomenclature History

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Previous Names: fj85b03, sb:eu1064, si:ch211-260p9.2, wu:fj85b03, zgc:152893

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have phosphatidylinositol phospholipase C activity. Predicted to be involved in several processes, including inositol trisphosphate biosynthetic process; phosphatidylinositol-mediated signaling; and release of sequestered calcium ion into cytosol. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 3. Orthologous to human PLCG2 (phospholipase C gamma 2).
Genome Resources: Alliance (1),  Gene:561747 (1),  Ensembl(GRCz11):ENSDARG00000068763 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu1064]
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa18057 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23252 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25057 Point Mutation Unknown Premature Stop ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH plcg2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    familial cold autoinflammatory syndrome 3 Alliance Familial cold autoinflammatory syndrome 3 614468
    Autoinflammation, antibody deficiency, and immune dysregulation syndrome 614878
    DISEASE ASSOCIATED WITH plcg2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process intracellular signal transduction (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA plcg2-201 (1)    Ensembl 4296
    plcg2-202 (1)    Ensembl 500
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM plcg2 No data available
    MARKER RELATIONSHIPS
    plcg2 Contained in: [BAC] CH211-260P9 (1)
    plcg2 Encodes: [EST] eu1064 (1), fj85b03
    [cDNA] MGC:152893 (1), MGC:191757 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001044968 (1) 4296 nt
    Genomic GenBank:BX511124 (1) 149227 nt
    Select Tool
    Polypeptide UniProtKB:Q08BR5 (1) 1240 aa
    Sequence Information (all 21)
    ORTHOLOGY for plcg2 ( Chr: 18 )
    CITATIONS (26)