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ZIRC
ZFIN ID: ZDB-GENE-030131-9498
Gene Name: methyltransferase like 3
Gene Symbol: mettl3    Nomenclature History

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Previous Names: fj82g07, wu:fj82g07, zgc:77093

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Exhibits mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity and mRNA (N6-adenosine)-methyltransferase activity. Involved in several processes, including Notch signaling pathway involved in arterial endothelial cell fate commitment; endothelial to hematopoietic transition; and hematopoietic stem cell proliferation. Predicted to localize to the RNA N6-methyladenosine methyltransferase complex and nuclear speck. Used to study infertility. Is expressed in several structures, including gill; heart; liver; nervous system; and pleuroperitoneal region. Orthologous to human METTL3 (methyltransferase like 3).
Genome Resources: Alliance (1),  Gene:100004398 (1),  Ensembl(GRCz11):ENSDARG00000012827 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Directly Submitted Expression Data: 1 figure (2 images) from Thisse et al., 2004 [MGC:77093]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb306 Indel Exon 1 Frameshift, Premature Stop TALEN
ihb307 Small Deletion Exon 1 Frameshift, Premature Stop TALEN
ioz12 Insertion Exon 3 Premature Stop CRISPR
la025876Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1579 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20914 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-mettl3 1
    MO1-mettl3 N/A 2
    TALEN1-mettl3 1
    DISEASE ASSOCIATED WITH mettl3 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH mettl3 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    infertility mettl3ihb307/ihb307(AB) standard conditions Xia et al., 2017
    mettl3ihb306/ihb306(AB) standard conditions Xia et al., 2017
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of apoptotic process (more)
    Cellular Component nuclear speck (more)
    Molecular Function mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity (more)
    GO Terms (all 40)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mettl3-201 (1)    Ensembl 1997
    ncRNA mettl3-002 (1)    Ensembl 684
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mettl3
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(CMV:GFP,CMV:mettl3) CMV GFPmettl3 Danio rerio 1 1
    MARKER RELATIONSHIPS
    mettl3 Contained in: [BAC] DKEY-85K7 (1) (order this)
    mettl3 Encodes: [EST] fj82g07
    [cDNA] MGC:77093 (1) (order this), MGC:174419 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_212780 (1) 1987 bp
    Genomic GenBank:BX005336 (1) 233826 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1R777 (1) 584 aa
    Sequence Clusters UniGene:77098 (1)
    Sequence Information (all 16)
    ORTHOLOGY for mettl3 ( Chr: 7 )
    CITATIONS (30)