ZFIN ID: ZDB-GENE-030131-9460
Gene Name: myeloid-specific peroxidase
Gene Symbol: mpx    Nomenclature History

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Previous Names: drf, fj80f04, mpo (1), myeloperoxidase (1), unm t30963, unm_sm681, unm_t30963, wu:fj80f04

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Exhibits peroxidase activity. Involved in inflammatory response; regulation of hydrogen peroxide metabolic process; and response to bacterium. Localizes to cytoplasm. Is expressed in several structures, including hematopoietic cell; hematopoietic system; mesoderm; pleuroperitoneal region; and post-vent region.
Genome Resources: Alliance (1),  Gene:337514 (1),  Ensembl(GRCz11):ENSDARG00000019521 (2)
GENE EXPRESSION
All Expression Data: 283 figures from 192 publications
Directly Submitted Expression Data: 3 figures (3 images) from Thisse et al., 2001 [cb1013]
Wild-type Stages, Structures: Segmentation:5-9 somites (11.66h-14.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
gl8 Point Mutation Unknown Unknown
sa18566 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21652 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34835 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sm681 Small Deletion Exon 13 Premature Stop ENU
    t30963 Point Mutation Unknown Unknown ENU
    DISEASE ASSOCIATED WITH mpx HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH mpx VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to bacterium (more)
    Cellular Component cytoplasm (more)
    Molecular Function peroxidase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mpx-201 (1)    Ensembl 3146
    mpx-202 (1)    Ensembl 3199
    ncRNA mpx-003 (1)    Ensembl 1481
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab5-mpx polyclonal IgG Rabbit IHC GeneTex
    5
    Ab1-mpx polyclonal Rabbit IHC 8
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mpx
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-8mpx:cxcr4b-EGFP) mpx cxcr4bEGFP Danio rerio 1 2
    Tg(-8mpx:EGFP-CAAX) mpx EGFP Danio rerio 1 4
    Tg(-8mpx:H2B-Cerulean-2A-mKOFP2-CAAX) mpx 2ACAAXCeruleanmKOFP2 Danio rerio 1 1
    Tg(-8mpx:KALTA4) mpx KALTA4 Danio rerio 1 5
    Tg(-8mpx:mCherry) mpx mCherry Danio rerio 1 5
    Tg(-8mpx:mCherry-CAAX) mpx CAAXmCherry Danio rerio 1 1
    Tg(mpx:Dendra2) mpx Dendra2 Danio rerio 1 19
    Tg(mpx:DsRed) mpx DsRed Danio rerio 1 2
    Tg(mpx:EGFP) mpx EGFP Danio rerio 1 11
    Tg(mpx:EGFP-Hsa.UTRN) mpx EGFP Danio rerioHomo sapiens 1 6
    Tg(mpx:GFP) mpx GFP Danio rerio 3 327
    Tg(mpx:Hsa.AKT1-EGFP) mpx EGFP Danio rerioHomo sapiens 1 4
    Tg(mpx:LIFEACT-RFP) mpx RFP Danio rerio 1 4
    Tg(mpx:LY-mKate2) mpx LYmKate2 Danio rerio 1 1
    Tg(mpx:lyn-EGFP) mpx EGFPlyn Danio rerio 1 2
    Tg(mpx:lyn_C466A-EGFP) mpx EGFPlyn Danio rerio 1 2
    Tg(mpx:mCherry) mpx mCherry Danio rerio 2 20
    Tg(mpx:mCherry,rac2) mpx mCherryrac2 Danio rerio 1 11
    Tg(mpx:mCherry,rac2_D57N) mpx mCherryrac2 Danio rerio 1 19
    Tg(mpx:mCherry-2A-rac1a) mpx 2AmCherryrac1a Danio rerio 1 2
    Tg(mpx:mCherry-Hsa.RAC1) mpx mCherry Danio rerioHomo sapiens 1 2
    Tg1(-8mpx:cxcr4b-EGFP) mpx cxcr4bEGFP Danio rerio 1 10
    Tg2(mpx:EGFP) mpx EGFP Danio rerio 1 1
    tg3(mpx:egfp) mpx EGFP Danio rerio 1 1
    TgBAC(mpx:CFP-DEVD-YFP) mpx CFPDEVDYFP Danio rerio 1 1
    TgBAC(mpx:Eco.BirA-Citrine) mpx Citrine Danio rerioEscherichia coli 1 3
    TgBAC(mpx:GAL4-VP16) mpx GAL4VP16 Danio rerio 1 12
    MARKER RELATIONSHIPS
    mpx Contained in: [BAC] CH73-340N8 (1)
    mpx Encodes: [EST] cb1013 (order this), fj80f04
    [cDNA] MGC:65945 (1), MGC:85760 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212779 (1) 3846 nt
    Genomic GenBank:CU681843 (1) 72220 nt
    Select Tool
    Polypeptide UniProtKB:F1R9R1 (1) 893 aa
    Sequence Information (all 37)
    ORTHOLOGY for mpx ( Chr: 10 )
    CITATIONS (391)