Gene

sik1

ID
ZDB-GENE-030131-9446
Name
salt-inducible kinase 1
Symbol
sik1 Nomenclature History
Previous Names
  • fj78h07
  • si:ch211-235e18.3
  • wu:fj78h07
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 30. Orthologous to several human genes including SIK1B (salt inducible kinase 1B (putative)).
Genome Resources
Note
None
Expression
All Expression Data
Fig. 1 from Klangnurak et al., 2018
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sik1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
early infantile epileptic encephalopathy 30 Alliance Epileptic encephalopathy, early infantile, 30 616341
Associated With sik1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR015940 Ubiquitin-associated domain
Domain IPR034672 Salt-Inducible kinase, catalytic domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Salt-Inducible kinase, catalytic domain Serine/threonine-protein kinase, active site Ubiquitin-associated domain
UniProtKB:A9JRA4 327
UniProtKB:A0A0G2L7B5 800
UniProtKB:B0S6K0 811
UniProtKB:Q502F3 527
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations