ZFIN ID: ZDB-GENE-030131-8774
Gene Name: myelin protein zero-like 2b
Gene Symbol: mpzl2b    Nomenclature History

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Previous Names: mpzl2, cb837 (1), eva1, wu:fb07b02 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Exhibits identical protein binding activity. Predicted to be involved in cell-cell adhesion. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness. Is expressed in several structures, including digestive system; epidermis; periderm; pronephric duct; and sensory system. Orthologous to human MPZL2 (myelin protein zero like 2).
Genome Resources: Alliance (1),  Gene:336830 (1),  Ensembl(GRCz11):ENSDARG00000027345 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011581Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la015672Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la015673Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la025040Tg Transgenic Insertion Unknown Unknown DNA
    la025041Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa209 Point Mutation Unknown Premature Stop ENU
    sa26531 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-mpzl2b
    1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mpzl2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Deafness, autosomal recessive 111 618145
    DISEASE ASSOCIATED WITH mpzl2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell-cell adhesion (more)
    Cellular Component integral component of membrane (more)
    Molecular Function identical protein binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000920 Myelin P0 protein-related
    Domain IPR003599 Immunoglobulin subtype
    Domain IPR007110 Immunoglobulin-like domain
    Domain IPR013106 Immunoglobulin V-set domain
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Family IPR029863 Myelin protein zero-like protein 2
    Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mpzl2b-201 (1)    Ensembl 1608
    ncRNA mpzl2b-002 (1) 528
    mpzl2b-003 (1) 1344
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mpzl2b No data available
    MARKER RELATIONSHIPS
    mpzl2b Contained in: [BAC] CH211-139A5 (1)
    mpzl2b Encodes: [EST] cb837 (1) (order this), fb07b02
    [cDNA] cssl:d174 (1), cssl:d204 (1), MGC:92213 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_212763 (1) 1392 bp
    Genomic GenBank:BX465852 (1) 160041 bp
    Select Tool
    Polypeptide UniProtKB:A2BGB5 (1) 199 aa
    Sequence Information (all 29)
    ORTHOLOGY for mpzl2b ( Chr: 5 )
    CITATIONS (32)