ZFIN ID: ZDB-GENE-030131-8557
Gene Name: cytoplasmic FMR1 interacting protein 1
Gene Symbol: cyfip1    Nomenclature History

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Previous Names: CY (1), CYFIP (1), fb15a06, wu:fb15a06 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have RNA 7-methylguanosine cap binding activity and actin filament binding activity. Predicted to be involved in modification of synaptic structure; plasma membrane bounded cell projection organization; and regulation of translation. Predicted to localize to SCAR complex; neuron projection; and synapse. Human ortholog(s) of this gene implicated in autism spectrum disorder and schizophrenia. Orthologous to human CYFIP1 (cytoplasmic FMR1 interacting protein 1).
Genome Resources: Alliance (1),  Gene:336613 (1),  Ensembl(GRCz11):ENSDARG00000044345 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7144298]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa2288 Point Mutation Unknown Premature Stop ENU
sa10367 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14676 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20750 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40737 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45259 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cyfip1
    1
    DISEASE ASSOCIATED WITH cyfip1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cyfip1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axon extension (more)
    Cellular Component cytoplasm (more)
    Molecular Function actin filament binding (more)
    GO Terms (all 24)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cyfip1-201 (1)    Ensembl 4645
    cyfip1-202 (1)    Ensembl 1654
    ncRNA cyfip1-003 (1)    Ensembl 510
    cyfip1-004 (1)    Ensembl 515
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cyfip1 No data available
    MARKER RELATIONSHIPS
    cyfip1 Contained in: [BAC] CH73-125I12 (1), DKEY-62E6 (1) (order this)
    cyfip1 Encodes: [EST] fb15a06, IMAGE:7144298 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212759 (1) 4127 nt
    Genomic GenBank:BX322552 (1) 230846 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1QE65 (1) 1253 aa
    Sequence Information (all 29)
    ORTHOLOGY for cyfip1 ( Chr: 6 )
    CITATIONS (27)