ZFIN ID: ZDB-GENE-030131-8312
Gene Name: VPS37A subunit of ESCRT-I
Gene Symbol: vps37a    Nomenclature History

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Previous Names: fb08f03, fj42c03, wu:fb08f03, wu:fj42c03 (1), zgc:77637 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Involved in locomotory behavior. Predicted to localize to the ESCRT I complex and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 53. Orthologous to human VPS37A (VPS37A subunit of ESCRT-I).
Genome Resources: Alliance (1),  Gene:336368 (1),  Ensembl(GRCz11):ENSDARG00000017119 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:73244]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7138466]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013576Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16986 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-vps37a N/A 1
    MO2-vps37a N/A 1
    PHENOTYPE
    Data: Fig. 4 from Zivony-Elboum et al., 2012
    Observed in:
    DISEASE ASSOCIATED WITH vps37a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hereditary spastic paraplegia 53 Alliance Spastic paraplegia 53, autosomal recessive 614898
    DISEASE ASSOCIATED WITH vps37a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process locomotory behavior (more)
    Cellular Component ESCRT I complex (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR009851 Modifier of rudimentary, Modr
    Family IPR037859 Vacuolar protein sorting-associated protein 37
    Homologous_superfamily IPR016135 Ubiquitin-conjugating enzyme/RWD-like
    Homologous_superfamily IPR029012 Helix hairpin bin domain superfamily
    Homologous_superfamily IPR037202 ESCRT assembly domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA vps37a-201 (1)    Ensembl 2002
    vps37a-202 (1)    Ensembl 443
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM vps37a No data available
    MARKER RELATIONSHIPS
    vps37a Contained in: [BAC] CH73-218C12 (1)
    vps37a Encodes: [EST] fb08f03, fj42c03, IMAGE:7138466 (1)
    [cDNA] MGC:73244 (1), MGC:77637 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199990 (1) 2022 nt
    Genomic GenBank:CT573256 (1) 100697 nt
    Select Tool
    Polypeptide UniProtKB:Q6P3K6 (1) 387 aa
    Sequence Information (all 22)
    ORTHOLOGY for vps37a ( Chr: 1 )
    CITATIONS (28)