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Gene

sox4a

ID
ZDB-GENE-030131-8290
Name
SRY-box transcription factor 4a
Symbol
sox4a Nomenclature History
Previous Names
  • sox4
  • wu:fb82f08 (1)
  • wu:fq41g10 (1)
  • zgc:65850
  • zgc:77392 (1)
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within closure of optic fissure and negative regulation of smoothened signaling pathway. Predicted to be located in nucleus. Is expressed in several structures, including anterior neural rod; digestive system; nervous system; neural tube; and periderm. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome and urinary bladder cancer. Orthologous to human SOX4 (SRY-box transcription factor 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
18 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sox4a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Coffin-Siris syndrome 10 618506
Associated With sox4a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR009071 High mobility group box domain
Family IPR017386 Transcription factor SOX-12/11/4
Homologous_superfamily IPR036910 High mobility group box domain superfamily
Domain Details Per Protein
Protein Length High mobility group box domain High mobility group box domain superfamily Transcription factor SOX-12/11/4
UniProtKB:Q6P0Z4 363
UniProtKB:Q6A3P6 357
UniProtKB:I3IT46 183
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations