ZFIN ID: ZDB-GENE-030131-7745
Gene Name: Cdc42 guanine nucleotide exchange factor (GEF) 9b
Gene Symbol: arhgef9b    Nomenclature History

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Previous Names: arhgef9, wu:fj33b10

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have guanyl-nucleotide exchange factor activity. Involved in filopodium assembly and sprouting angiogenesis. Is expressed in caudal artery; caudal vein plexus; dorsal aorta; and intersegmental vessel. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 8. Orthologous to human ARHGEF9 (Cdc42 guanine nucleotide exchange factor 9).
Genome Resources: Alliance (1),  Gene:560923 (1),  Ensembl(GRCz11):ENSDARG00000078624 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa35637 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • um45 Small Deletion Unknown Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-arhgef9b N/A 1
    DISEASE ASSOCIATED WITH arhgef9b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    early infantile epileptic encephalopathy 8 Alliance Epileptic encephalopathy, early infantile, 8 300607
    DISEASE ASSOCIATED WITH arhgef9b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process sprouting angiogenesis (more)
    Molecular Function guanyl-nucleotide exchange factor activity (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA arhgef9b-201 (1)    Ensembl 4616
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM arhgef9b No data available
    MARKER RELATIONSHIPS
    arhgef9b Contained in: [BAC] CH73-119D10, CH211-205H12, DKEY-20D18 (order this)
    arhgef9b Encodes: [EST] fj33b10
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001161663 (1) 1854 nt
    Genomic GenBank:AL844570 240816 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8QCF3 (1) 550 aa
    Sequence Information (all 34)
    ORTHOLOGY for arhgef9b ( Chr: 14 )
    CITATIONS (20)