Gene

arhgef9b

ID

ZDB-GENE-030131-7745

Name

Cdc42 guanine nucleotide exchange factor (GEF) 9b

Symbol

arhgef9b Nomenclature History

Previous Names

arhgef9
wu:fj33b10

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have guanyl-nucleotide exchange factor activity. Involved in filopodium assembly and sprouting angiogenesis. Is expressed in caudal artery; caudal vein plexus; dorsal aorta; and intersegmental vessel. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 8. Orthologous to human ARHGEF9 (Cdc42 guanine nucleotide exchange factor 9).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Wakayama et al., 2015

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Wakayama et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arhgef9b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
developmental and epileptic encephalopathy 8	Alliance	Developmental and epileptic encephalopathy 8	300607

Associated With arhgef9b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR001452	SH3 domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR035728	Rho guanine nucleotide exchange factor 9, SH3 domain
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily

Domain Details Per Protein

Protein	Length	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	PH-like domain superfamily	Pleckstrin homology domain	Rho guanine nucleotide exchange factor 9, SH3 domain	SH3 domain	SH3-like domain superfamily
UniProtKB:A0A2R8QCR3 InterPro	418
UniProtKB:A0A2R8QEM2 InterPro	530
UniProtKB:A0A2R8RV69 InterPro	464
UniProtKB:A0A2R8Q3X9 InterPro	546
UniProtKB:A0A2R8QB69 InterPro	485
UniProtKB:A0A2R8QCF3 InterPro	550
UniProtKB:A0A2R8RVC8 InterPro	480
UniProtKB:F1Q628 InterPro	514
UniProtKB:A0A2R8Q858 InterPro	461
UniProtKB:A0A2R8QGA7 InterPro	509
UniProtKB:A0A2R8QKQ0 InterPro	468
UniProtKB:C1J0C6 InterPro	236