ZFIN ID: ZDB-GENE-030131-73
Gene Name: transforming growth factor, beta-induced
Gene Symbol: tgfbi    Nomenclature History

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Previous Names: big-h3 (1), etID38199.14 (1), hm:zeh0933, wu:fa13f05 (1), zgc:110495

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have cell adhesion molecule binding activity. Involved in cellular response to xenobiotic stimulus and muscle fiber development. Predicted to localize to extracellular matrix and extracellular space. Is expressed in several structures, including head mesenchyme; liver; neural crest cell; paraxial mesoderm; and splanchnocranium. Human ortholog(s) of this gene implicated in corneal dystrophy (multiple). Orthologous to human TGFBI (transforming growth factor beta induced).
Genome Resources: Alliance (1),  Gene:321421 (1),  Ensembl(GRCz11):ENSDARG00000071586 (2)
GENE EXPRESSION
All Expression Data: 17 figures from 10 publications
Directly Submitted Expression Data: 6 figures (23 images) from Thisse et al., 2004 [IMAGE:6903641]
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la018916Tg Transgenic Insertion Unknown Unknown DNA
la018917Tg Transgenic Insertion Unknown Unknown DNA
sa22487 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39002 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42397 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tgfbi N/A 1
    MO2-tgfbi N/A 2
    DISEASE ASSOCIATED WITH tgfbi HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    epithelial basement membrane dystrophy Alliance Corneal dystrophy, epithelial basement membrane 121820
    granular corneal dystrophy 1 Alliance Corneal dystrophy, Groenouw type I 121900
    granular corneal dystrophy 2 Alliance Corneal dystrophy, Avellino type 607541
    lattice corneal dystrophy Alliance Corneal dystrophy, lattice type I 122200
    Reis-Bucklers corneal dystrophy Alliance Corneal dystrophy, Reis-Bucklers type 608470
    Thiel-Behnke corneal dystrophy Alliance Corneal dystrophy, Thiel-Behnke type 602082
    Corneal dystrophy, lattice type IIIA 608471
    DISEASE ASSOCIATED WITH tgfbi VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to xenobiotic stimulus (more)
    Cellular Component extracellular matrix (more)
    Molecular Function collagen binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tgfbi-201 (1)    Ensembl 3037
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tgfbi No data available
    MARKER RELATIONSHIPS
    tgfbi Contained in: [BAC] DKEYP-110E4 (1)
    tgfbi Contains: [SNP] rs3728631 (1), rs3728642 (1), rs3728643 (1), rs3728644 (1), rs3728645 (1)
    tgfbi Encodes: [EST] fa13f05 (1), IMAGE:6903641 (1), zeh0933
    [cDNA] MGC:110495 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_182862 (1) 3046 nt
    Genomic GenBank:BX323077 (1) 195732 nt
    Select Tool
    Polypeptide UniProtKB:A0A0B5JSG0 (1) 677 aa
    Sequence Information (all 22)
    ORTHOLOGY for tgfbi ( Chr: 14 )
    CITATIONS (45)