Gene

tgfbi

ID
ZDB-GENE-030131-73
Name
transforming growth factor, beta-induced
Symbol
tgfbi Nomenclature History
Previous Names
  • big-h3 (1)
  • etID38199.14 (1)
  • hm:zeh0933
  • wu:fa13f05 (1)
  • zgc:110495
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have cell adhesion molecule binding activity. Involved in cellular response to xenobiotic stimulus and muscle fiber development. Predicted to localize to extracellular matrix and extracellular space. Is expressed in several structures, including head mesenchyme; liver; neural crest cell; paraxial mesoderm; and splanchnocranium. Human ortholog(s) of this gene implicated in corneal dystrophy (multiple). Orthologous to human TGFBI (transforming growth factor beta induced).
Genome Resources
Note
None
Expression
All Expression Data
19 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Kim et al., 2009
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tgfbi Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
epithelial basement membrane dystrophy Alliance Corneal dystrophy, epithelial basement membrane 121820
granular corneal dystrophy 1 Alliance Corneal dystrophy, Groenouw type I 121900
granular corneal dystrophy 2 Alliance Corneal dystrophy, Avellino type 607541
lattice corneal dystrophy Alliance Corneal dystrophy, lattice type I 122200
Reis-Bucklers corneal dystrophy Alliance Corneal dystrophy, Reis-Bucklers type 608470
Thiel-Behnke corneal dystrophy Alliance Corneal dystrophy, Thiel-Behnke type 602082
Corneal dystrophy, lattice type IIIA 608471
Associated With tgfbi Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000782 FAS1 domain
Domain IPR011489 EMI domain
Family IPR016666 TGF beta-induced protein/periostin
Family IPR032954 Transforming growth factor-beta-induced protein ig-h3
Homologous_superfamily IPR036378 FAS1 domain superfamily
Domain Details Per Protein
Protein Length EMI domain FAS1 domain FAS1 domain superfamily TGF beta-induced protein/periostin Transforming growth factor-beta-induced protein ig-h3
UniProtKB:A0A0B5JSG0 677
UniProtKB:Q503K1 677
UniProtKB:Q7T1R2 677
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations