ZFIN ID: ZDB-GENE-030131-7116
Gene Name: paraoxonase 2
Gene Symbol: pon2    Nomenclature History

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Previous Names: fk84f07, wu:fk84f07, zgc:77556

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have arylesterase activity. Is expressed in cranium. Human ortholog(s) of this gene implicated in artery disease (multiple); neurodegenerative disease (multiple); type 2 diabetes mellitus; and vascular dementia. Orthologous to several human genes including PON2 (paraoxonase 2).
Genome Resources: Alliance (1),  Gene:335176 (1),  Ensembl(GRCz11):ENSDARG00000016856 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Directly Submitted Expression Data: 1 figure (2 images) from Thisse et al., 2004 [MGC:77556]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:6911665]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Days 14-20 (14d-21d, 6.2mm, 10 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fh450 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36123 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH pon2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {Coronary artery disease, susceptibility to}
    DISEASE ASSOCIATED WITH pon2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component cellular_component (more)
    Molecular Function arylesterase activity (more)
    GO Terms (all 2)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pon2-201 (1)    Ensembl 1169
    ncRNA pon2-002 (1)    Ensembl 853
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pon2 No data available
    MARKER RELATIONSHIPS
    pon2 Contained in: [BAC] DKEY-56F14 (1) (order this)
    pon2 Encodes: [EST] fk84f07, IMAGE:6911665 (1)
    [cDNA] MGC:77556 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212734 (1) 1220 nt
    Genomic GenBank:CR848666 (1) 106065 nt
    Select Tool
    Polypeptide UniProtKB:Q6NXA5 (1) 355 aa
    Sequence Information (all 11)
    ORTHOLOGY for pon2 ( Chr: 16 )
    CITATIONS (24)