Gene
psmc3
- ID
- ZDB-GENE-030131-666
- Name
- proteasome 26S subunit, ATPase 3
- Symbol
- psmc3 Nomenclature History
- Previous Names
-
- wu:fb39a02
- zgc:86713 (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity; hydrolase activity; and proteasome-activating activity. Involved in lens development in camera-type eye and semicircular canal fusion. Predicted to be located in cytoplasm and nucleus. Predicted to be part of proteasome regulatory particle, base subcomplex. Is expressed in inner ear. Used to study cataract and sensorineural hearing loss. Orthologous to human PSMC3 (proteasome 26S subunit, ATPase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
-
- GEO (1) Expression Atlas (1) UCSC scRNA-seq (1)
- Thisse Expression Data
-
- IMAGE:6896890 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Kröll-Hermi et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Deafness, cataract, impaired intellectual development, and polyneuropathy | 619354 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003960 | ATPase, AAA-type, conserved site |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR003959 | ATPase, AAA-type, core |
| Domain | IPR032501 | Proteasomal ATPase OB C-terminal domain |
| Domain | IPR041569 | AAA ATPase, AAA+ lid domain |
| Family | IPR005937 | 26S proteasome regulatory subunit P45-like |
| Family | IPR035254 | 26S Proteasome regulatory subunit 6A |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | 26S Proteasome regulatory subunit 6A | 26S proteasome regulatory subunit P45-like | AAA ATPase, AAA+ lid domain | AAA+ ATPase domain | ATPase, AAA-type, conserved site | ATPase, AAA-type, core | P-loop containing nucleoside triphosphate hydrolase | Proteasomal ATPase OB C-terminal domain |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6IQL5
|
404 | ||||||||
|
UniProtKB:F1QUQ7
|
404 | ||||||||
|
UniProtKB:A0A0R4ILA8
|
427 | ||||||||
|
UniProtKB:A0A1D5NS51
|
41 |
Interactions and Pathways
No data available
Plasmids
No data available