Gene

psmc3

ID

ZDB-GENE-030131-666

Name

proteasome 26S subunit, ATPase 3

Symbol

psmc3 Nomenclature History

Previous Names

wu:fb39a02
zgc:86713 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have ATP binding activity and hydrolase activity. Predicted to be involved in positive regulation of RNA polymerase II transcriptional preinitiation complex assembly. Predicted to localize to proteasome regulatory particle, base subcomplex. Orthologous to human PSMC3 (proteasome 26S subunit, ATPase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:6896890 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Kröll-Hermi et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With psmc3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Deafness, cataract, impaired intellectual development, and polyneuropathy	619354

Associated With psmc3 Via Experimental Models

Human Disease	Fish	Conditions	Citations
cataract	WT + MO1-psmc3	standard conditions	Kröll-Hermi et al., 2020
cataract	WT + CRISPR2-psmc3	standard conditions	Kröll-Hermi et al., 2020
sensorineural hearing loss	WT + CRISPR2-psmc3	standard conditions	Kröll-Hermi et al., 2020

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR003960	ATPase, AAA-type, conserved site
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR003959	ATPase, AAA-type, core
Domain	IPR032501	Proteasomal ATPase OB C-terminal domain
Domain	IPR041569	AAA ATPase, AAA+ lid domain
Family	IPR005937	26S proteasome regulatory subunit P45-like
Family	IPR035254	26S Proteasome regulatory subunit 6A
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	26S Proteasome regulatory subunit 6A	26S proteasome regulatory subunit P45-like	AAA ATPase, AAA+ lid domain	AAA+ ATPase domain	ATPase, AAA-type, conserved site	ATPase, AAA-type, core	P-loop containing nucleoside triphosphate hydrolase	Proteasomal ATPase OB C-terminal domain
UniProtKB:A0A1D5NS51 InterPro	41
UniProtKB:F1QUQ7 InterPro	404
UniProtKB:Q6IQL5 InterPro	404
UniProtKB:A0A0R4ILA8 InterPro	427

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
aberrant processed transcript	psmc3-203 (1) Ensembl	508 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	psmc3-201 (1) Ensembl	1811 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	psmc3-202 (1) Ensembl	1554 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations