ZFIN ID: ZDB-GENE-030131-6008
Gene Name: VPS51 subunit of GARP complex
Gene Symbol: vps51    Nomenclature History

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Previous Names: ang2 (1), c11orf2, fat free (1), fat-free (1), ffr (1), fi30b05, wu:fi30b05

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Exhibits ADP-ribosylation factor binding activity. Involved in several processes, including Golgi organization; lipid digestion; and regulation of phospholipase activity. Predicted to localize to EARP complex; Golgi apparatus; and membrane. Is expressed in digestive system; head; heart; and trunk musculature. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia. Orthologous to human VPS51 (VPS51 subunit of GARP complex).
Genome Resources: Alliance (1),  Gene:559339 (1),  Ensembl(GRCz11):ENSDARG00000062016 (1)
GENE EXPRESSION
All Expression Data: Fig. 6 from Ho et al., 2006
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
p9emcf Point Mutation Unknown Premature Stop
sa11553 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14534 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-vps51 N/A 1
    MO2-vps51 N/A 1
    MO4-vps51 N/A 1
    MO5-vps51 N/A 1
    DISEASE ASSOCIATED WITH vps51 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Pontocerebellar hypoplasia, type 13 618606
    DISEASE ASSOCIATED WITH vps51 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process Golgi organization (more)
    Cellular Component EARP complex (more)
    Molecular Function ADP-ribosylation factor binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA vps51-201 (1)    Ensembl 2716
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM vps51 No data available
    MARKER RELATIONSHIPS
    vps51 Contained in: [BAC] DKEY-48M5 (1) (order this), DKEY-56F11 (1) (order this)
    vps51 Contains: [SNP] rs3728314 (1)
    vps51 Encodes: [EST] fi30b05
    [cDNA] MGC:194641 (1), MGC:194642 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001042735 (1) 2484 nt
    Genomic GenBank:BX088530 165564 nt
    Select Tool
    Polypeptide UniProtKB:F1QLF1 (1) 827 aa
    Sequence Information (all 20)
    ORTHOLOGY for vps51 ( Chr: 10 )
    CITATIONS (32)