Gene
vps51
- ID
- ZDB-GENE-030131-6008
- Name
- VPS51 subunit of GARP complex
- Symbol
- vps51 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Enables small GTPase binding activity. Acts upstream of or within several processes, including Golgi organization; lipid digestion; and regulation of phospholipase activity. Predicted to be located in recycling endosome. Predicted to be part of EARP complex and GARP complex. Predicted to be active in membrane. Is expressed in digestive system; head; heart; and trunk musculature. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 13. Orthologous to human VPS51 (VPS51 subunit of GARP complex).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb826 | Allele with one deletion | Exon 5 | Unknown | CRISPR | |
| p9emcf | Allele with one point mutation | Unknown | Premature Stop | not specified | |
| sa11553 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14534 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-vps51 | Zebrafish Nomenclature Committee | |
| MO1-vps51 | N/A | Ho et al., 2006 |
| MO2-vps51 | N/A | Ho et al., 2006 |
| MO4-vps51 | N/A | Ho et al., 2006 |
| MO5-vps51 | N/A | Ho et al., 2006 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pontocerebellar hypoplasia type 13 | Alliance | Pontocerebellar hypoplasia, type 13 | 618606 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cullin repeat-like-containing domain superfamily | Vacuolar protein sorting-associated protein 51 |
|---|---|---|---|---|
| UniProtKB:Q155U0 | InterPro | 827 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-48M5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-56F11 | Ho et al., 2006 | |
| Contains | SNP | rs3728314 | ZFIN Curated Data | |
| Encodes | EST | fi30b05 | ||
| Encodes | cDNA | MGC:194641 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194642 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001042735 (1) | 2484 nt | ||
| Genomic | GenBank:BX088530 (1) | 165564 nt | ||
| Polypeptide | UniProtKB:Q155U0 (1) | 827 aa |
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- White, R.J., Mackay, E., Wilson, S.W., Busch-Nentwich, E.M. (2022) Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants. eLIFE. 11:
- Sun, H., Chen, M., Wang, Z., Zhao, G., Liu, J.X. (2019) Transcriptional profiles and copper stress responses in zebrafish cox17 mutants. Environmental pollution (Barking, Essex : 1987). 256:113364
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Otis, J.P., and Farber, S.A. (2013) Imaging vertebrate digestive function and lipid metabolism in vivo.. Drug Discovery Today: Disease Models. 10(1):e11-e16
- Carten, J.D., Bradford, M.K., and Farber, S. (2011) Visualizing digestive organ morphology and function using differential fatty acid metabolism in live zebrafish. Developmental Biology. 360(2):276-85
- Liu, H.Y., Lee, N., Tsai, T.Y., and Ho, S.Y. (2010) Zebrafish fat-free, a novel Arf effector, regulates phospholipase D to mediate lipid and glucose metabolism. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1801(12):1330-1340
- Hama, K., Provost, E., Baranowski, T.C., Rubinstein, A.L., Anderson, J.L., Leach, S.D., and Farber, S.A. (2009) In vivo imaging of zebrafish digestive organ function using multiple quenched fluorescent reporters. American journal of physiology. Gastrointestinal and liver physiology. 296(2):G445-G453
- Ho, S.Y., Lorent, K., Pack, M., and Farber, S.A. (2006) Zebrafish fat-free is required for intestinal lipid absorption and Golgi apparatus structure. Cell Metabolism. 3(4):289-300
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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