header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-030131-5697
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.
Gene Name: complement component 4
Gene Symbol: c4
Sequence Ontology ID : SO:0001217

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: wu:fi14a03 (2)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Location: Chr: 15 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have endopeptidase inhibitor activity. Predicted to be involved in complement activation. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in  ...
GENE EXPRESSION
All Expression Data: 2 figures from Wang et al., 2008
Wild-type Stages, Structures: Cleavage:64-cell (2.0h-2.25h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12226 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa22685 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa22686 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa22687 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa35935 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • sa35936 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa35937 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa42584 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa45547 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa45548 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH c4 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH c4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process complement activation (more)
    Cellular Component extracellular region (more)
    Molecular Function endopeptidase inhibitor activity (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000020 (1)
  • InterPro:IPR001134 (1)
  • InterPro:IPR001599 (1)
  • InterPro:IPR002890 (1)
  • InterPro:IPR008930 (1)
  • InterPro:IPR008993 (1)
  • InterPro:IPR009048 (1)
  • InterPro:IPR011625 (1)
  • InterPro:IPR011626 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR014756 (1)
  • InterPro:IPR018081 (1)
  • InterPro:IPR018933 (1)
  • InterPro:IPR019742 (1)
  • InterPro:IPR036595 (1)
  • InterPro:IPR037569 (1)
  • InterPro:IPR041425 (1)
  • InterPro:IPR041555 (1)
  • PROSITE:PS00477 (1)
  • PROSITE:PS01178 (1)
  • PROSITE:PS50189 (1)
  • Pfam:PF00207 (1)
  • Pfam:PF01759 (1)
  • Pfam:PF01821 (1)
  • Pfam:PF01835 (1)
  • Pfam:PF07677 (1)
  • Pfam:PF07678 (1)
  • Pfam:PF07703 (1)
  • Pfam:PF17790 (1)
  • Pfam:PF17791 (1)
    • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA c4-201 (1) 7274
    Select Tool
    c4-202 (1) 611
    Select Tool
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM c4 No data available
    MARKER RELATIONSHIPS
    c4 Contained in: [BAC] CH211-162K9 (1) (order this)
    c4 Encodes: [EST] fi14a03
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_005157372 (1) 7210 bp
    Select Tool
    Genomic GenBank:AL935181 (1) 156592 bp
    Select Tool
    Polypeptide UniProtKB:F1Q4X5 (1) 1700 aa
    Select Tool
    Sequence Clusters UniGene:111094 (1)
    Sequence Information (all 17)
    OTHER c4 GENE PAGES
  • Alliance (1)
  • Gene:566261 (1)
  • VEGA:OTTDARG00000040158 (1)
  • Ensembl(GRCz11):ENSDARG00000015065 (2)
    • ORTHOLOGY for c4 ( Chr: 15 )
    CITATIONS (21)