ZFIN ID: ZDB-GENE-030131-5697
Gene Name: complement component 4
Gene Symbol: c4    Nomenclature History

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Previous Name: wu:fi14a03 (2)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have endopeptidase inhibitor activity. Predicted to be involved in complement activation. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune hypersensitivity disease (multiple); complement deficiency (multiple); renal cell carcinoma; and rheumatoid arthritis. Is expressed in liver. Orthologous to human C4A (complement C4A (Rodgers blood group)) and C4B (complement C4B (Chido blood group)).
Genome Resources: Alliance (1),  Gene:566261 (1),  Ensembl(GRCz11):ENSDARG00000015065 (2)
GENE EXPRESSION
All Expression Data: 2 figures from Wang et al., 2008
Wild-type Stages, Structures: Cleavage:64-cell (2.0h-2.25h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12226 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22685 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22686 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22687 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35935 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa35936 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35937 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42584 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45547 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45548 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH c4 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH c4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process complement activation (more)
    Cellular Component extracellular region (more)
    Molecular Function endopeptidase inhibitor activity (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000020 Anaphylatoxin/fibulin
    Domain IPR001134 Netrin domain
    Domain IPR001599 Alpha-2-macroglobulin
    Domain IPR002890 Macroglobulin domain
    Homologous_superfamily IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
    Homologous_superfamily IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
    Domain IPR009048 Alpha-macroglobulin, receptor-binding
    Domain IPR011625 Alpha-2-macroglobulin, bait region domain
    Domain IPR011626 Alpha-macroglobulin-like, TED domain
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Homologous_superfamily IPR014756 Immunoglobulin E-set
    Homologous_superfamily IPR018081 Anaphylatoxin, complement system
    Domain IPR018933 Netrin module, non-TIMP type
    Conserved_site IPR019742 Alpha-2-macroglobulin, conserved site
    Homologous_superfamily IPR036595 Alpha-macroglobulin, receptor-binding domain superfamily
    Family IPR037569 Complement component C4-A
    Domain IPR041425 Complement C3/4/5, macroglobulin domain MG1
    Domain IPR041555 Macroglobulin domain MG3
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA c4-201 (1)    Ensembl 7274
    c4-202 (1)    Ensembl 611
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM c4 No data available
    MARKER RELATIONSHIPS
    c4 Contained in: [BAC] CH211-162K9 (1)
    c4 Encodes: [EST] fi14a03
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_005157372 (1) 7210 bp
    Genomic GenBank:AL935181 (1) 156592 bp
    Select Tool
    Polypeptide UniProtKB:F1Q4X5 (1) 1700 aa
    Sequence Information (all 16)
    ORTHOLOGY for c4 ( Chr: 15 )
    CITATIONS (22)