Gene
c4
- ID
- ZDB-GENE-030131-5697
- Name
- complement component 4
- Symbol
- c4 Nomenclature History
- Previous Names
-
- wu:fi14a03 (2)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in complement activation. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in liver.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019742 | Alpha-2-macroglobulin, conserved site |
| Conserved_site | IPR047565 | Alpha-macroglobulin-like, thiol-ester bond-forming region |
| Domain | IPR000020 | Anaphylatoxin/fibulin |
| Domain | IPR001134 | Netrin domain |
| Domain | IPR001599 | Alpha-2-macroglobulin |
| Domain | IPR002890 | Macroglobulin domain |
| Domain | IPR009048 | Alpha-macroglobulin, receptor-binding |
| Domain | IPR011625 | Alpha-2-macroglobulin, bait region domain |
| Domain | IPR011626 | Alpha-macroglobulin-like, TED domain |
| Domain | IPR018933 | Netrin module, non-TIMP type |
| Domain | IPR041425 | Complement C3/4/5, macroglobulin domain MG1 |
| Domain | IPR041555 | Macroglobulin domain MG3 |
| Family | IPR050473 | Alpha-2-macroglobulin/Complement system |
| Homologous_superfamily | IPR008930 | Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid |
| Homologous_superfamily | IPR008993 | Tissue inhibitor of metalloproteinases-like, OB-fold |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
| Homologous_superfamily | IPR018081 | Anaphylatoxin, complement system |
| Homologous_superfamily | IPR036595 | Alpha-macroglobulin, receptor-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha-2-macroglobulin | Alpha-2-macroglobulin, bait region domain | Alpha-2-macroglobulin/Complement system | Alpha-2-macroglobulin, conserved site | Alpha-macroglobulin-like, TED domain | Alpha-macroglobulin-like, thiol-ester bond-forming region | Alpha-macroglobulin, receptor-binding | Alpha-macroglobulin, receptor-binding domain superfamily | Anaphylatoxin, complement system | Anaphylatoxin/fibulin | Complement C3/4/5, macroglobulin domain MG1 | Immunoglobulin E-set | Immunoglobulin-like fold | Macroglobulin domain | Macroglobulin domain MG3 | Netrin domain | Netrin module, non-TIMP type | Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid | Tissue inhibitor of metalloproteinases-like, OB-fold |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1Q4X5 | InterPro | 1700 | |||||||||||||||||||
| UniProtKB:A0A8M9PCH5 | InterPro | 1680 |
Interactions and Pathways
No data available
Plasmids
No data available