Gene

c4

ID
ZDB-GENE-030131-5697
Name
complement component 4
Symbol
c4 Nomenclature History
Previous Names
  • wu:fi14a03 (2)
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have serine-type endopeptidase inhibitor activity. Predicted to be involved in complement activation. Predicted to localize to extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune disease (multiple); complement component 4b deficiency; and renal cell carcinoma. Orthologous to human C4B (complement C4B (Chido blood group)).
Genome Resources
Note
None
Expression
All Expression Data
2 figures from Wang et al., 2008
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With c4 Human Ortholog
No data available
Associated With c4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019742 Alpha-2-macroglobulin, conserved site
Domain IPR000020 Anaphylatoxin/fibulin
Domain IPR001134 Netrin domain
Domain IPR001599 Alpha-2-macroglobulin
Domain IPR002890 Macroglobulin domain
Domain IPR009048 Alpha-macroglobulin, receptor-binding
Domain IPR011625 Alpha-2-macroglobulin, bait region domain
Domain IPR011626 Alpha-macroglobulin-like, TED domain
Domain IPR018933 Netrin module, non-TIMP type
Domain IPR041425 Complement C3/4/5, macroglobulin domain MG1
Domain IPR041555 Macroglobulin domain MG3
Family IPR037569 Complement component C4-A
Homologous_superfamily IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Homologous_superfamily IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR014756 Immunoglobulin E-set
Homologous_superfamily IPR018081 Anaphylatoxin, complement system
Homologous_superfamily IPR036595 Alpha-macroglobulin, receptor-binding domain superfamily
Domain Details Per Protein
Protein Length Alpha-2-macroglobulin Alpha-2-macroglobulin, bait region domain Alpha-2-macroglobulin, conserved site Alpha-macroglobulin-like, TED domain Alpha-macroglobulin, receptor-binding Alpha-macroglobulin, receptor-binding domain superfamily Anaphylatoxin, complement system Anaphylatoxin/fibulin Complement C3/4/5, macroglobulin domain MG1 Complement component C4-A Immunoglobulin E-set Immunoglobulin-like fold Macroglobulin domain Macroglobulin domain MG3 Netrin domain Netrin module, non-TIMP type Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid Tissue inhibitor of metalloproteinases-like, OB-fold
UniProtKB:X1WBY4 203
UniProtKB:A0A2R8RSM2 1669
UniProtKB:A6H8S2 942
UniProtKB:F1Q4X5 1700
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations