ZFIN Gene: c4

ZFIN ID: ZDB-GENE-030131-5697

ZFIN ID: ZDB-GENE-030131-5697

Gene Name:

complement component 4

Gene Symbol:

c4 Nomenclature History

Previous Name:

wu:fi14a03 (2)

Gene Type:

protein_coding_gene

Location:

Chr: 15 Mapping Details/Browsers

Description:

Predicted to have endopeptidase inhibitor activity. Predicted to be involved in complement activation. Predicted to localize to extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune hypersensitivity disease (multiple); complement component 4b deficiency; renal cell carcinoma; and rheumatoid arthritis. Orthologous to human C4B (complement C4B (Chido blood group)).

Genome Resources:

Alliance (1), Gene:566261 (1), Ensembl(GRCz11):ENSDARG00000015065 (2)

GENE EXPRESSION
All Expression Data:	2 figures from Wang et al., 2008
Wild-type Stages, Structures:	Cleavage:64-cell (2.0h-2.25h) to Adult (90d-730d, breeding adult)
	liver whole organism
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa12226	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa22685	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa22686	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa22687	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa35935	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this)
sa35936	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa35937	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa42584	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa45547	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa45548	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)

PHENOTYPE No data available

DISEASE ASSOCIATED WITH c4 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH c4 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	complement activation (more)
Cellular Component	extracellular region (more)
Molecular Function	endopeptidase inhibitor activity (more)

GO Terms (all 4)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	c4-201 (1)	7274	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	c4-202 (1)	611	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM c4 No data available

MARKER RELATIONSHIPS

c4 Contained in:	[BAC] CH211-162K9 (1)
c4 Encodes:	[EST] fi14a03

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_005157372 (1)	7210 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:AL935181 (1)	156592 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:F1Q4X5 (1)	1700 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 16)

ORTHOLOGY for c4 ( Chr: 15 )

CITATIONS (22)

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