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ZIRC
ZFIN ID: ZDB-GENE-030131-555
Gene Name: KRIT1 ankyrin repeat containing
Gene Symbol: krit1    Nomenclature History

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Previous Names: ccm1 (2), fb36f07, san (1), santa (1), wu:fb36f07, zgc:63585

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Involved in several processes, including circulatory system development; endothelial cell morphogenesis; and negative regulation of endothelial cell differentiation. Predicted to localize to the plasma membrane. Human ortholog(s) of this gene implicated in cerebral cavernous malformation and cerebral cavernous malformation 1. Is expressed in head; notochord; post-vent region; posterior cardinal vein; and ventricular zone. Orthologous to human KRIT1 (KRIT1 ankyrin repeat containing).
Genome Resources: Alliance (1),  Gene:321836 (1),  Ensembl(GRCz11):ENSDARG00000098916 (1)
GENE EXPRESSION
All Expression Data: 5 figures from 5 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:63585]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
m775 Point Mutation Intron 13 Splicing Variant, Inframe Deletion ENU
s234 Unknown Unknown Unknown ENU
s610 Unknown Unknown Unknown ENU
sa44926 Point Mutation Unknown Unknown ENU
t26458 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ty219c Point Mutation Exon 15 Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-krit1 N/A 6
    MO2-krit1 N/A 5
    MO3-krit1 N/A 1
    DISEASE ASSOCIATED WITH krit1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    cerebral cavernous malformation 1 Alliance Cavernous malformations of CNS and retina 116860
    Cerebral cavernous malformations-1 116860
    Hyperkeratotic cutaneous capillary-venous malformations associated with cerebral capillary malformations 116860
    DISEASE ASSOCIATED WITH krit1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterior/posterior axis specification (more)
    Cellular Component plasma membrane (more)
    GO Terms (all 19)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA krit1-201 (1)    Ensembl 2881
    ncRNA krit1-003 (1)    Ensembl 804
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM krit1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:krit1-IRES-EGFP) hsp70l EGFPIRESkrit1 Danio rerio 1 1
    Tg(UAS:EGFP-krit1,cryaa:EGFP) cryaaUAS EGFPkrit1 Danio rerio 1 1
    MARKER RELATIONSHIPS
    krit1 Contained in: [BAC] CH211-153F2 (1) (order this)
    krit1 Encodes: [EST] fb36f07
    [cDNA] MGC:63585 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_199572 (1) 1668 bp
    Genomic GenBank:CR855331 (1) 165603 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IW01 (1) 741 aa
    Sequence Clusters UniGene:4553 (1)
    Sequence Information (all 18)
    ORTHOLOGY for krit1 ( Chr: 19 )
    CITATIONS (46)