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ZIRC
ZFIN ID: ZDB-GENE-030131-5486
Gene Name: nanog homeobox
Gene Symbol: nanog    Nomenclature History

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Previous Names: fd20a07, nanog-like (1), wu:fd19e04, wu:fd20a07 (1), zgc:193933

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Exhibits protein homodimerization activity and sequence-specific DNA binding activity. Involved in several processes, including cortical microtubule organization; epiboly; and regulation of gene expression. Predicted to localize to the nucleus. Is expressed in several structures, including blastoderm; blastodisc; liver; neuronal stem cell; and reproductive system. Orthologous to several human genes including NANOG (Nanog homeobox).
Genome Resources: Alliance (1),  Gene:792333 (1),  Ensembl(GRCz11):ENSDARG00000075113 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a166 Small Deletion Exon 1 Frameshift, Premature Stop TALEN
ihb97 Small Deletion Unknown Unknown TALEN
ihb98 Insertion Unknown Unknown TALEN
ihb168 Indel Unknown Unknown CRISPR
ihb169 Indel Unknown Unknown CRISPR
la022843Tg Transgenic Insertion Unknown Unknown DNA
m1435 Small Deletion Exon 1 Frameshift, Premature Stop TALEN
sa44104 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-nanog 1
    CRISPR2-nanog 1
    MO1-nanog N/A 6
    MO2-nanog N/A 2
    MO3-nanog N/A 1
    TALEN1-nanog
    1
    TALEN2-nanog 1
    TALEN3-nanog 1
    DISEASE ASSOCIATED WITH nanog HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH nanog VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process gastrulation (more)
    Cellular Component nucleus (more)
    Molecular Function sequence-specific DNA binding (more)
    GO Terms (all 16)
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    AB1-nanog polyclonal Rabbit IHC, WB 1
    Ab2-nanog polyclonal IgG Rabbit WB ABclonal
    1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nanog No data available
    MARKER RELATIONSHIPS
    nanog Contains: [SNP] rs3729322 (1), rs3729323 (1)
    nanog Encodes: [EST] fd19e04, fd20a07
    [cDNA] MGC:193930 (1), MGC:193933 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001098392 (1)
    Genomic GenBank:CABZ01072215 (1) 6926 bp
    Polypeptide UniProtKB:A5JNG8 (1) 384 aa
    Sequence Clusters UniGene:46544 (1)
    Sequence Information (all 24)
    ORTHOLOGY for nanog ( Chr: 24 )
    CITATIONS (65)