| ZFIN ID: ZDB-GENE-030131-5486 |
| Gene Name: | nanog homeobox | |||||||||||||
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| Gene Symbol: | nanog Nomenclature History |
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| Previous Names: | fd20a07, nanog-like (1), wu:fd19e04, wu:fd20a07 (1), zgc:193933 | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 24 Mapping Details/Browsers | |||||||||||||
| Description: | Exhibits protein homodimerization activity and sequence-specific DNA binding activity. Involved in several processes, including cortical microtubule organization; epiboly; and regulation of gene expression. Predicted to localize to the nucleus. Is expressed in several structures, including blastoderm; blastodisc; liver; neuronal stem cell; and reproductive system. Orthologous to several human genes including NANOG (Nanog homeobox). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:792333 (1), Ensembl(GRCz11):ENSDARG00000075113 (1) | |||||||||||||
| All Expression Data: | 13 figures from 9 publications |
| Wild-type Stages, Structures: | Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult) |
| Curated Microarray Expression: | GEO (1) |
| Allele | Type | Localization | Consequence | Mutagen | Suppliers |
|---|---|---|---|---|---|
| a166 | Small Deletion | Exon 1 | Frameshift, Premature Stop | TALEN | |
| ihb97 | Small Deletion | Unknown | Unknown | TALEN | |
| ihb98 | Insertion | Unknown | Unknown | TALEN | |
| ihb168 | Indel | Unknown | Unknown | CRISPR | |
| ihb169 | Indel | Unknown | Unknown | CRISPR | |
| la022843Tg | Transgenic Insertion | Unknown | Unknown | DNA | |
| m1435 | Small Deletion | Exon 1 | Frameshift, Premature Stop | TALEN | |
| sa44104 | Point Mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Publications |
|---|---|---|
| CRISPR1-nanog | 1 | |
| CRISPR2-nanog | 1 | |
| MO1-nanog | N/A | 6 |
| MO2-nanog | N/A | 2 |
| MO3-nanog | N/A | 1 |
| TALEN1-nanog |
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1 |
| TALEN2-nanog | 1 | |
| TALEN3-nanog | 1 |
| Ontology | GO Term |
|---|---|
| Biological Process | gastrulation (more) |
| Cellular Component | nucleus (more) |
| Molecular Function | sequence-specific DNA binding (more) |
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| Name | Type | Isotype | Host Organism | Assay | Source | Publications |
|---|---|---|---|---|---|---|
| AB1-nanog | polyclonal | Rabbit | IHC, WB | 1 | ||
| Ab2-nanog | polyclonal | IgG | Rabbit | WB |
ABclonal
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1 |
| nanog Contains: | [SNP] rs3729322 (1), rs3729323 (1) |
| nanog Encodes: |
[EST]
fd19e04,
fd20a07
[cDNA] MGC:193930 (1), MGC:193933 (1) |
| Type | Accession # | Length (bp/aa) | Analysis |
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| RNA | RefSeq:NM_001098392 (1) |
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| Genomic | GenBank:CABZ01072215 (1) | 6926 bp |
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| Polypeptide | UniProtKB:A5JNG8 (1) | 384 aa |
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| Sequence Clusters | UniGene:46544 (1) |
