ZFIN ID: ZDB-GENE-030131-4631
Gene Name: tocopherol (alpha) transfer protein
Gene Symbol: ttpa    Nomenclature History

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Previous Names: wu:fd44e05, zgc:66361

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have lipid transfer activity and vitamin E binding activity. Involved in central nervous system development and chordate embryonic development. Predicted to localize to the late endosome. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Is expressed in several structures, including eye; immature eye; liver; neural tube; and tail bud. Orthologous to human TTPA (alpha tocopherol transfer protein).
Genome Resources: Alliance (1),  Gene:325906 (1),  Ensembl(GRCz11):ENSDARG00000027584 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:66361]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-ttpa N/A 1
MO2-ttpa N/A 1
DISEASE ASSOCIATED WITH ttpa HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial isolated deficiency of vitamin E Alliance Ataxia with isolated vitamin E deficiency 277460
DISEASE ASSOCIATED WITH ttpa VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process central nervous system development (more)
Cellular Component late endosome (more)
Molecular Function lipid transfer activity (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR001251 CRAL-TRIO lipid binding domain
Domain IPR011074 CRAL/TRIO, N-terminal domain
Homologous_superfamily IPR036273 CRAL/TRIO, N-terminal domain superfamily
Homologous_superfamily IPR036865 CRAL-TRIO lipid binding domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ttpa-202 (1)    Ensembl 1837
ncRNA ttpa-003 (1)    Ensembl 1045
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-ttpa polyclonal IgG Rabbit WB 1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ttpa No data available
MARKER RELATIONSHIPS
ttpa Contained in: [BAC] DKEY-181M9 (1) (order this)
ttpa Encodes: [EST] fd44e05
[cDNA] MGC:66361 (1), MGC:192302 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_199731 (1) 1858 bp
Genomic GenBank:BX248497 (1) 145610 bp
Select Tool
Polypeptide UniProtKB:B0S5J5 (1) 285 aa
Sequence Information (all 16)
ORTHOLOGY for ttpa ( Chr: 2 )
CITATIONS (19)