ZFIN ID: ZDB-GENE-030131-433
Gene Name: SET nuclear proto-oncogene b
Gene Symbol: setb    Nomenclature History

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Previous Names: wu:fb30g11, wu:fd16c08

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have chromatin binding activity and histone binding activity. Involved in neuromast development. Predicted to localize to nucleus. Is expressed in several structures, including digestive system; nervous system; optic cup; otic vesicle; and tail bud. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human SET (SET nuclear proto-oncogene).
Genome Resources: Alliance (1),  Gene:321714 (1),  Ensembl(GRCz11):ENSDARG00000003920 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12096 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-setb
    1
    MO1-setb N/A 1
    MO2-setb N/A 1
    MO3-setb N/A 1
    DISEASE ASSOCIATED WITH setb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Mental retardation, autosomal dominant 58 618106
    DISEASE ASSOCIATED WITH setb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process neuromast development (more)
    Cellular Component nucleus (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA setb-201 (1)    Ensembl 1862
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-set polyclonal Rabbit IHC 1
    Ab2-set polyclonal Goat WB Santa Cruz Biotechnology, Inc.
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM setb No data available
    MARKER RELATIONSHIPS
    setb Contained in: [BAC] DKEY-156G19 (1) (order this)
    setb Encodes: [EST] fb30g11, fd16c08 (1), fu06a08 (1) (order this)
    [cDNA] MGC:77152 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201468 (1) 1869 nt
    Genomic GenBank:CU466275 (1) 104457 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QJ70 (1) 287 aa
    Sequence Information (all 20)
    ORTHOLOGY for setb ( Chr: 21 )
    CITATIONS (21)