ZFIN ID: ZDB-GENE-030131-2221
Gene Name: SET nuclear proto-oncogene a
Gene Symbol: seta    Nomenclature History

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Previous Names: ik:tdsubc_2c6, wu:fb99h10, xx:tdsubc_2c6

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have chromatin binding activity and histone binding activity. Predicted to be involved in nucleosome assembly. Predicted to localize to nucleus. Is expressed in central nervous system; optic cup; otic vesicle; and sensory system. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to several human genes including SET (SET nuclear proto-oncogene).
Genome Resources: Alliance (1),  Gene:323501 (1),  Ensembl(GRCz11):ENSDARG00000031495 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la016328Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-seta N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH seta HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Mental retardation, autosomal dominant 58 618106
    DISEASE ASSOCIATED WITH seta VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process nucleosome assembly (more)
    Cellular Component nucleus (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA seta-201 (1)    Ensembl 1835
    ncRNA seta-002 (1)    Ensembl 630
    seta-003 (1)    Ensembl 859
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-set polyclonal Rabbit IHC 1
    Ab2-set polyclonal Goat WB Santa Cruz Biotechnology, Inc.
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM seta No data available
    MARKER RELATIONSHIPS
    seta Contained in: [BAC] CH211-51H9 (1)
    seta Encodes: [EST] fb99h10, tdsubc_2c6 (1)
    [cDNA] MGC:56333 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201475 (1) 1715 nt
    Genomic GenBank:BX088526 (1) 187161 nt
    Select Tool
    Polypeptide UniProtKB:Q7ZUY0 (1) 269 aa
    Sequence Information (all 12)
    ORTHOLOGY for seta ( Chr: 8 )
    CITATIONS (22)