ZFIN ID: ZDB-GENE-030131-3777
Gene Name: TAR DNA binding protein
Gene Symbol: tardbp    Nomenclature History

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Previous Names: wu:fb77f02 (1), wu:fc52g10 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have double-stranded DNA binding activity; mRNA 3'-UTR binding activity; and single-stranded RNA binding activity. Involved in several processes, including axon extension; neuromuscular junction development; and skeletal muscle tissue development. Predicted to localize to the cytoplasm; nucleoplasm; and ribonucleoprotein complex. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; and motor neuron disease. Is expressed in several structures, including brain; eye; gill; heart; and liver. Orthologous to human TARDBP (TAR DNA binding protein).
Genome Resources: Alliance (1),  Gene:325052 (1),  Ensembl(GRCz11):ENSDARG00000040031 (1)
GENE EXPRESSION
All Expression Data: 9 figures from 6 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu466]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fh301 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • mde150 Small Deletion Exon 2 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
    mde198 Small Deletion Exon 2 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
    mde201 Small Deletion Exon 2 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
    mde897 Small Deletion Exon 6 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
    mde909 Small Deletion Exon 6 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
    mde948 Small Deletion Exon 6 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
    sa40778 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40779 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tardbp_unrecovered Point Mutation Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tardbp
    1
    CRISPR2-tardbp
    2
    CRISPR3-tardbp
    1
    MO1-tardbp N/A 4
    DISEASE ASSOCIATED WITH tardbp HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    amyotrophic lateral sclerosis type 10 Alliance Amyotrophic lateral sclerosis 10, with or without FTD 612069
    Frontotemporal lobar degeneration, TARDBP-related 612069
    DISEASE ASSOCIATED WITH tardbp VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    amyotrophic lateral sclerosis WT + MO1-tardbp standard conditions Kabashi et al., 2010
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axon extension (more)
    Cellular Component nucleoplasm (more)
    Molecular Function nucleic acid binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000504 RNA recognition motif domain
    Homologous_superfamily IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    Homologous_superfamily IPR035979 RNA-binding domain superfamily
    Domain IPR041105 TAR DNA-binding protein 43, N-terminal
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tardbp-201 (1)    Ensembl 2798
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-tardbp polyclonal Rabbit IHC, WB Proteintech
    4
    Ab5-tardbp monoclonal IgG2a Rat WB 2
    Ab3-tardbp polyclonal Rabbit Novus Biologicals, LLC
    2
    Ab6-tardbp polyclonal Rabbit Sigma-Aldrich
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tardbp No data available
    MARKER RELATIONSHIPS
    tardbp Contained in: [BAC] DKEY-148L2 (1) (order this)
    tardbp Encodes: [EST] eu466 (1), fb77f02, fc52g10
    [cDNA] MGC:55939 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_201476 (1) 2787 bp
    Genomic GenBank:BX663614 (1) 191715 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8Q8T5 (1) 415 aa
    Sequence Clusters UniGene:2409 (1)
    Sequence Information (all 18)
    ORTHOLOGY for tardbp ( Chr: 6 )
    CITATIONS (42)