ZFIN ID: ZDB-GENE-030131-3777
Gene Name: TAR DNA binding protein
Gene Symbol: tardbp
Sequence Ontology ID : SO:0000704

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Previous Names: wu:fb77f02 (1), wu:fc52g10 (1)

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(Including Attributions)
Location: Chr: 6 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have distal enhancer DNA-binding activity transcription activator activity, RNA polymerase II-specific and nucleic acid binding activity; involved in several processes, including axon  ...
GENE EXPRESSION
All Expression Data: 9 figures from 6 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu466]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fh301 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • mde150 Small Deletion Exon 2 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
    mde198 Small Deletion Exon 2 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
    mde201 Small Deletion Exon 2 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
    mde897 Small Deletion Exon 6 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
    mde909 Small Deletion Exon 6 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
    mde948 Small Deletion Exon 6 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
    sa40778 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40779 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tardbp_unrecovered Point Mutation Unknown Unknown ENU
    Targeting reagents:
    PHENOTYPE
    Data: 9 figures from 6 publications
    Observed in:
    DISEASE ASSOCIATED WITH tardbp HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    amyotrophic lateral sclerosis type 10 Amyotrophic lateral sclerosis 10, with or without FTD 612069
    Frontotemporal lobar degeneration, TARDBP-related 612069
    DISEASE ASSOCIATED WITH tardbp VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axon extension (more)
    Molecular Function nucleic acid binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000504 (1)
  • InterPro:IPR012677 (1)
  • InterPro:IPR035979 (1)
  • PROSITE:PS50102 (1)
  • Pfam:PF00076 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA tardbp-201 (1) 2798
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM tardbp No data available
    MARKER RELATIONSHIPS
    tardbpContained in: [BAC] DKEY-148L2 (1) (order this)
    tardbpEncodes: [EST] eu466 (1), fb77f02, fc52g10
    [cDNA] MGC:55939 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_201476 (1) 2787bp
    Genomic GenBank:BX663614 (1) 191715bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8Q8T5 (1) 415aa
    Sequence Clusters UniGene:2409 (1)
    Sequence Information (all 18)
    OTHER tardbp GENE PAGES
  • Alliance (1)
  • Gene:325052 (1)
  • VEGA:OTTDARG00000019917 (1)
  • ORTHOLOGY for tardbp (Chr: 6)
    CITATIONS (38)