ZFIN ID: ZDB-GENE-030131-3421
Gene Name: DGCR8 microprocessor complex subunit
Gene Symbol: dgcr8    Nomenclature History

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Previous Names: sb:eu827, sb:eu832, si:ch211-106a19.4, wu:fc23f08, wu:fc38f06

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to contribute to ribonuclease III activity. Predicted to be involved in primary miRNA processing. Predicted to localize to microprocessor complex. Orthologous to human DGCR8 (DGCR8 microprocessor complex subunit).
Genome Resources: Alliance (1),  Gene:563963 (1),  Ensembl(GRCz11):ENSDARG00000035564 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu827]
  1 figure (1 image) from Thisse et al., 2005 [eu832]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
dgcr8_unrecovered Point Mutation Unknown Unknown ENU
fh344 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa223 Point Mutation Unknown Premature Stop ENU
    sa40420 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zf1064 Indel Exon 4 Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    TALEN1-dgcr8 1
    PHENOTYPE
    Data: Fig. 1 from Liu et al., 2017
    Observed in:
    DISEASE ASSOCIATED WITH dgcr8 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH dgcr8 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process primary miRNA processing (more)
    Cellular Component microprocessor complex (more)
    Molecular Function heme binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dgcr8-201 (1)    Ensembl 4703
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dgcr8
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    TgBAC(LOXP-dgcr8-LOXP) dgcr8LOXP Danio rerio 1 1
    MARKER RELATIONSHIPS
    dgcr8 Contained in: [BAC] CH211-106A19 (1)
    dgcr8 Encodes: [EST] bn0aa053za02 (1), eu827 (1), eu832 (1), fc23f08 (1), fc38f06
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001122749 (1) 4703 nt
    Genomic GenBank:BX088551 (1) 184417 nt
    Select Tool
    Polypeptide UniProtKB:A2BEG3 (1) 782 aa
    Sequence Information (all 17)
    ORTHOLOGY for dgcr8 ( Chr: 5 )
    CITATIONS (30)