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ZIRC
ZFIN ID: ZDB-GENE-030131-3196
Gene Name: structural maintenance of chromosomes 3
Gene Symbol: smc3    Nomenclature History

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Previous Names: cspg6 (1), im:7142991, wu:fb22e01, wu:fc30d07

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in mitotic sister chromatid cohesion and regulation of transcription by RNA polymerase II. Predicted to localize to the chromosome and nucleus. Used to study Cornelia de Lange syndrome. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 3. Is expressed in several structures, including axis; blastoderm; digestive system; head; and nervous system. Orthologous to human SMC3 (structural maintenance of chromosomes 3).
Genome Resources: Alliance (1),  Gene:324475 (1),  Ensembl(GRCz11):ENSDARG00000019000 (1)
DISEASE ASSOCIATED WITH smc3 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Cornelia de Lange syndrome 3 Alliance Cornelia de Lange syndrome 3 610759
DISEASE ASSOCIATED WITH smc3 VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
Cornelia de Lange syndrome WT + MO1-smc3 standard conditions Xu et al., 2015
GENE ONTOLOGY
Ontology GO Term
Biological Process mitotic sister chromatid cohesion (more)
Cellular Component chromosome (more)
Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific (more)
GO Terms (all 7)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA smc3-201 (1)    Ensembl 4680
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM smc3 No data available
MARKER RELATIONSHIPS
smc3 Contained in: [BAC] CH211-91I13 (1) (order this), CH211-194K1 (1) (order this), CH211-223C9 (1) (order this)
smc3 Contains: [SNP] rs3729203 (1), rs3729204 (1), rs3729205 (1), rs3729206 (1), rs3729207 (1), rs3729208 (1)
smc3 Encodes: [EST] fb22e01, fc30d07, IMAGE:7141067 (1) (order this), IMAGE:7142991 (1) (order this)
[cDNA] MGC:55484 (1) (order this), MGC:193111 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_214689 (1) 4286 bp
Genomic GenBank:BX649294 (1) 209223 bp Blast at MegaBLAST
Polypeptide UniProtKB:B2GRT6 (1) 1216 aa
Sequence Clusters UniGene:24937 (1)
Sequence Information (all 25)
ORTHOLOGY for smc3 ( Chr: 22 )
CITATIONS (41)