Gene

smc3

ID
ZDB-GENE-030131-3196
Name
structural maintenance of chromosomes 3
Symbol
smc3 Nomenclature History
Previous Names
  • cspg6 (1)
  • im:7142991
  • wu:fb22e01
  • wu:fc30d07
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in mitotic sister chromatid cohesion and regulation of transcription by RNA polymerase II. Predicted to localize to chromosome, centromeric region and nucleus. Is expressed in several structures, including axis; blastoderm; digestive system; head; and nervous system. Used to study Cornelia de Lange syndrome. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 3. Orthologous to human SMC3 (structural maintenance of chromosomes 3).
Genome Resources
Note
None
Expression
All Expression Data
10 figures from 5 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With smc3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Cornelia de Lange syndrome 3 Alliance Cornelia de Lange syndrome 3 610759
Associated With smc3 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003395 RecF/RecN/SMC, N-terminal
Domain IPR010935 SMCs flexible hinge
Domain IPR041741 Structural maintenance of chromosomes 3, ABC domain, eukaryotic
Family IPR024704 Structural maintenance of chromosomes protein
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036277 SMCs flexible hinge superfamily
Domain Details Per Protein
Protein Length P-loop containing nucleoside triphosphate hydrolase RecF/RecN/SMC, N-terminal SMCs flexible hinge SMCs flexible hinge superfamily Structural maintenance of chromosomes 3, ABC domain, eukaryotic Structural maintenance of chromosomes protein
UniProtKB:A0A0R4ITA5 1162
UniProtKB:B2GRT6 1216
UniProtKB:Q803N2 1216
UniProtKB:Q1LVV8 1216
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations