ZFIN ID: ZDB-GENE-030131-2908
Gene Name: cytochrome P450, family 26, subfamily b, polypeptide 1
Gene Symbol: cyp26b1    Nomenclature History

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Previous Names: dol, fc21d03, stocksteif (1), wu:fc21d03, wu:fc26h10, zgc:76999

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have retinoic acid 4-hydroxylase activity. Involved in several processes, including animal organ morphogenesis; negative regulation of retinoic acid receptor signaling pathway; and retinoic acid catabolic process. Predicted to localize to the endoplasmic reticulum and endoplasmic reticulum membrane. Is expressed in several structures, including brain; gill; hindbrain neural keel; pleuroperitoneal region; and skeletal system. Orthologous to human CYP26B1 (cytochrome P450 family 26 subfamily B member 1).
Genome Resources: Alliance (1),  Gene:324188 (1),  Ensembl(GRCz11):ENSDARG00000077121 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b1024 Point Mutation Exon 6 Nonsynonymous, Premature Stop ENU
la025910Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa3 Point Mutation Unknown Splice Site ENU
    t24295 Unknown Unknown Unknown
  • European Zebrafish Resource Center (EZRC) (order this)
  • ti230g Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cyp26b1 N/A 4
    MO2-cyp26b1 N/A 1
    MO3-cyp26b1 N/A 1
    MO4-cyp26b1 N/A 1
    MO5-cyp26b1 N/A 2
    PHENOTYPE
    Data: 24 figures from 9 publications
    Observed in:
    DISEASE ASSOCIATED WITH cyp26b1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Craniosynostosis with radiohumeral fusions and other skeletal and craniofacial anomalies 614416
    DISEASE ASSOCIATED WITH cyp26b1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of retinoic acid receptor signaling pathway (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function retinoic acid 4-hydroxylase activity (more)
    GO Terms (all 27)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR017972 Cytochrome P450, conserved site
    Family IPR001128 Cytochrome P450
    Family IPR002403 Cytochrome P450, E-class, group IV
    Homologous_superfamily IPR036396 Cytochrome P450 superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cyp26b1-201 (1)    Ensembl 3869
    ncRNA cyp26b1-002 (1)    Ensembl 579
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cyp26b1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    TgBAC(cyp26b1:Citrine) cyp26b1 Citrine Danio rerio 1 2
    TgBAC(cyp26b1:YFP) cyp26b1 YFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    cyp26b1 Contained in: [BAC] CH73-51F7 (1), CH73-368P22 (1), CH211-197C14
    cyp26b1 Encodes: [EST] fc21d03, fc26h10 (1)
    [cDNA] MGC:76999 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212666 (1) 3348 nt
    Genomic GenBank:AL935122 198363 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4I9F4 (1) 511 aa
    Sequence Information (all 18)
    ORTHOLOGY for cyp26b1 ( Chr: 7 )
    CITATIONS (93)