Gene

sgk1

ID
ZDB-GENE-030131-2860
Name
serum/glucocorticoid regulated kinase 1
Symbol
sgk1 Nomenclature History
Previous Names
  • sgk (1)
  • cb1083 (1)
  • wu:fc20a09
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to enable potassium channel regulator activity and protein serine/threonine kinase activity. Acts upstream of or within inflammatory response. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including blood vasculature; epidermal cell; epiphysis; pronephric duct; and ventral mesoderm. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SGK1 (serum/glucocorticoid regulated kinase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
16 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sgk1 Human Ortholog
No data available
Associated With sgk1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR000961 AGC-kinase, C-terminal
Domain IPR017892 Protein kinase, C-terminal
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length AGC-kinase, C-terminal Protein kinase, ATP binding site Protein kinase, C-terminal Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:E9QEW2 305
UniProtKB:E9QI98 229
UniProtKB:Q7ZTW4 433
UniProtKB:E9QIF7 264
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations