ZFIN ID: ZDB-GENE-030131-2042
Gene Name: VPS35 retromer complex component
Gene Symbol: vps35    Nomenclature History

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Previous Names: si:rp71-34g2.3, wu:fa66e03, wu:fb95c08 (1), zgc:136268

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to be involved in intracellular protein transport and retrograde transport, endosome to Golgi. Predicted to localize to late endosome and retromer complex. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 17. Orthologous to human VPS35 (VPS35 retromer complex component).
Genome Resources: Alliance (1),  Gene:561697 (1),  Ensembl(GRCz11):ENSDARG00000008224 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6907955]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7159390]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fcc403Gt Transgenic Insertion Unknown Splicing Variant DNA
sa9031 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11695 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa15228 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40982 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH vps35 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Parkinson's disease 17 Alliance {Parkinson disease 17} 614203
    DISEASE ASSOCIATED WITH vps35 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein transport (more)
    Cellular Component retromer, cargo-selective complex (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA vps35-201 (1)    Ensembl 3573
    vps35-203 (1)    Ensembl 752
    ncRNA vps35-002 (1)    Ensembl 763
    vps35-004 (1)    Ensembl 646
    vps35-005 (1)    Ensembl 701
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM vps35 No data available
    MARKER RELATIONSHIPS
    vps35 Contained in: [BAC] RP71-34G2
    vps35 Encodes: [EST] fa66e03 (1), fb95c08, IMAGE:6907955 (1), IMAGE:7159390 (1)
    [cDNA] MGC:136268 (1), MGC:162844 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001025517 (1) 763 nt
    Genomic GenBank:AL928906 (1) 161527 nt
    Select Tool
    Polypeptide UniProtKB:Q6ZM34 (1) 831 aa
    Sequence Information (all 23)
    ORTHOLOGY for vps35 ( Chr: 7 )
    CITATIONS (25)