Gene

prex1

ID
ZDB-GENE-030131-1428
Name
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Symbol
prex1 Nomenclature History
Previous Names
  • si:dkey-48j7.2 (1)
  • wu:fb71c09 (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within nodal signaling pathway. Predicted to be active in plasma membrane. Is expressed in endoderm. Orthologous to human PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Woo et al., 2012
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Woo et al., 2012
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With prex1 Human Ortholog
No data available
Associated With prex1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain IPR000219 Dbl homology (DH) domain
Domain IPR000591 DEP domain
Domain IPR001478 PDZ domain
Domain IPR001849 Pleckstrin homology domain
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR035899 Dbl homology (DH) domain superfamily
Homologous_superfamily IPR036034 PDZ superfamily
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Dbl homology (DH) domain Dbl homology (DH) domain superfamily DEP domain Guanine-nucleotide dissociation stimulator, CDC24, conserved site PDZ domain PDZ superfamily PH-like domain superfamily Pleckstrin homology domain Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:F1QQK7 1608
UniProtKB:F1R6J2 1622
UniProtKB:B0UYE5 56
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations