header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-030131-1428
Gene Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Gene Symbol: prex1    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: si:dkey-48j7.2 (1), wu:fb71c09 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have Rac guanyl-nucleotide exchange factor activity. Involved in nodal signaling pathway. Predicted to localize to the plasma membrane. Is expressed in endoderm. Orthologous to human PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1).
Genome Resources: Alliance (1),  Gene:570984 (1),  Ensembl(GRCz11):ENSDARG00000075793 (2)
GENE EXPRESSION
All Expression Data: Fig. 6 from Woo et al., 2012
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Gastrula:75%-epiboly (8.0h-9.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa7614 Point Mutation Unknown Missense ENU
sa12745 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17372 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17713 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21298 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21299 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21300 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27208 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34408 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41212 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41213 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41214 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-prex1
    2
    MO1-prex1 N/A 2
    PHENOTYPE
    Data: Fig. 6 from Woo et al., 2012
    Observed in:
    DISEASE ASSOCIATED WITH prex1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH prex1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process nodal signaling pathway (more)
    Cellular Component plasma membrane (more)
    Molecular Function guanyl-nucleotide exchange factor activity (more)
    GO Terms (all 6)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA prex1-202 (1)    Ensembl 551
    prex1-203 (1)    Ensembl 7803
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM prex1 No data available
    MARKER RELATIONSHIPS
    prex1 Contained in: [BAC] DKEY-5D4 (1) (order this), DKEY-48J7 (1) (order this), DKEY-183P4 (1) (order this)
    prex1 Encodes: [EST] fb71c09
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_694535 (1)
    Genomic GenBank:CR847543 (1) 207382 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1R6J2 (1) 1622 aa
    Sequence Clusters UniGene:121759 (1)
    Sequence Information (all 24)
    ORTHOLOGY for prex1 ( Chr: 8 )
    CITATIONS (21)