Gene
cpb1
- ID
- ZDB-GENE-030131-1132
- Name
- carboxypeptidase B1 (tissue)
- Symbol
- cpb1 Nomenclature History
- Previous Names
-
- wu:fb60d07
- wu:fb69b08
- zte141 (1)
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable metallocarboxypeptidase activity. Acts upstream of or within cellular response to xenobiotic stimulus. Predicted to be active in extracellular space. Is expressed in liver. Orthologous to several human genes including CPB1 (carboxypeptidase B1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa10544 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13299 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24436 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24437 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45818 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Carboxypeptidase, activation peptide | Carboxypeptidase B, carboxypeptidase domain | Metallocarboxypeptidase-like, propeptide | Peptidase M14, carboxypeptidase A |
|---|---|---|---|---|---|---|
| UniProtKB:F1QJN9 | InterPro | 416 | ||||
| UniProtKB:Q6NWD1 | InterPro | 414 | ||||
| UniProtKB:A0A8M1NG52 | InterPro | 265 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-65O9 | ZFIN Curated Data | |
| Contains | SNP | rs3729315 | ZFIN Curated Data | |
| Contains | SNP | rs3729316 | ZFIN Curated Data | |
| Contains | SNP | rs3729317 | ZFIN Curated Data | |
| Contains | SNP | rs3729318 | ZFIN Curated Data | |
| Encodes | EST | fb60d07 | ||
| Encodes | EST | fb69b08 | ||
| Encodes | EST | IMAGE:6961467 | ||
| Encodes | cDNA | MGC:171910 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001328425 (1) | 2220 nt | ||
| Genomic | GenBank:AL935306 (1) | 207183 nt | ||
| Polypeptide | UniProtKB:F1QJN9 (1) | 416 aa |
- Song, Y., Chen, W., Zhu, B., Ge, W. (2022) Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary. Frontiers in cell and developmental biology. 9:750888
- Akula, S., Hellman, L., Avilés, F.X., Wernersson, S. (2021) Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases. Developmental and comparative immunology. 127:104273
- Meng, H., Shang, Y., Cheng, Y., Wang, K., Yu, J., Cao, P., Fan, S., Li, Y., Cui, J. (2021) Knockout of zebrafish colony-stimulating factor 1 receptor by CRISPR/Cas9 affects metabolism and locomotion capacity. Biochemical and Biophysical Research Communications. 551:93-99
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Wu, S.Y., Yang, W.Y., Cheng, C.C., Lin, K.H., Sampurna, B.P., Chan, S.M., Yuh, C.H. (2020) Low molecular weight fucoidan inhibits hepatocarcinogenesis and nonalcoholic fatty liver disease in zebrafish via ASGR/STAT3/HNF4A signaling. Clinical and translational medicine. 10:e252
- Murdoch, C.C., Espenschied, S.T., Matty, M.A., Mueller, O., Tobin, D.M., Rawls, J.F. (2019) Intestinal Serum amyloid A suppresses systemic neutrophil activation and bactericidal activity in response to microbiota colonization. PLoS pathogens. 15:e1007381
- Mesquita, S.R., van Drooge, B.L., Oliveira, E., Grimalt, J.O., Barata, C., Vieira, N., Guimarães, L., Piña, B. (2015) Differential embryotoxicity of the organic pollutants in rural and urban air particles. Environmental pollution (Barking, Essex : 1987). 206:535-542
- Carlson, P., Smalley, D.M., and Van Beneden, R.J. (2013) Proteomic analysis of arsenic-exposed zebrafish (Danio rerio) identifies altered expression in proteins involved in fibrosis and lipid uptake in a gender-specific manner. Toxicological sciences : an official journal of the Society of Toxicology. 134(1):83-91
- Zheng, W., Xu, H., Lam, S.H., Luo, H., Karuturi, R.K., and Gong, Z. (2013) Transcriptomic analyses of sexual dimorphism of the zebrafish liver and the effect of sex hormones. PLoS One. 8(1):e53562
- Mohseny, A.B., Xiao, W., Carvalho, R., Spaink, H.P., Hogendoorn, P.C., and Cleton-Jansen, AM. (2012) An osteosarcoma zebrafish model implicates Mmp-19 and Ets-1 as well as reduced host immune response in angiogenesis and migration. The Journal of pathology. 227(2):245-253
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