ZFIN ID: ZDB-GENE-030128-2
Gene Name: myelin basic protein a
Gene Symbol: mbpa    Nomenclature History

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Previous Names: mbp, cb274 (1), fj33b11, wu:fj33b11, wu:fq15b02, zgc:136630

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to be a structural constituent of myelin sheath. Localizes to myelin sheath and plasma membrane. Is expressed in several structures, including EVL; male organism; nervous system; otic vesicle; and periderm. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human MBP (myelin basic protein).
Genome Resources: Alliance (1),  Gene:326281 (1),  Ensembl(GRCz11):ENSDARG00000036186 (2)
GENE EXPRESSION
All Expression Data: 152 figures from 85 publications
Directly Submitted Expression Data: 3 figures (8 images) from Thisse et al., 2001 [cb274]
  4 figures (3 images) from Rauch et al., 2003 [fq15b02]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-mbpa
2
CRISPR2-mbpa
2
CRISPR3-mbpa
2
CRISPR4-mbpa
2
MO1-mbpa N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH mbpa HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH mbpa VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Cellular Component myelin sheath (more)
Molecular Function structural constituent of myelin sheath (more)
GO Terms (all 4)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA mbpa-201 (1)    Ensembl 1719
mbpa-202 (1)    Ensembl 1610
mbpa-203 (1)    Ensembl 761
mbpa-205 (1)    Ensembl 581
mbpa-206 (1)    Ensembl 861
mbpa-207 (1)    Ensembl 497
mbpa-208 (1)    Ensembl 737
mbpa-209 (1)    Ensembl 761
mbpa-210 (1)    Ensembl 560
mbpa-211 (1)    Ensembl 869
ncRNA mbpa-006 (1)    Ensembl 1043
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-mbp polyclonal Rabbit IHC 34
CONSTRUCTS WITH SEQUENCES FROM mbpa
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(1mbp:EGFP) mbpamyl7 EGFP Danio rerio 1 14
Tg(mbp:EGFP) mbpa EGFP Danio rerio 1 17
Tg(mbp:EGFP-CAAX) mbpa EGFP Danio rerio 1 25
Tg(mbpa:Citrine) mbpa Citrine Danio rerio 1 1
tg(mbpa:dendra2) mbpa Dendra2 Danio rerio 1 1
tg(mbpa:dendra2-caax) mbpa CAAXDendra2 Danio rerio 1 2
tg(mbpa:dendra2-utr) mbpa Dendra2UTR Danio rerio 1 1
Tg(mbpa:EGFP-CAAX) mbpa CAAXEGFP Danio rerio 1 1
Tg(mbpa:GAL4-VP16) mbpa GAL4VP16 Danio rerio 1 5
Tg(mbpa:GAL4-VP16,myl7:Cerulean) mbpamyl7 CeruleanGAL4VP16 Danio rerio 1 2
Tg(mbpa:KillerRed) mbpa KillerRed Danio rerio 1 1
Tg(mbpa:MA-Cerulean) mbpa CeruleanMA Danio rerio 1 1
Tg(mbpa:mCherry,cafyna) mbpa fynamCherry Danio rerio 1 3
Tg(mbpa:mCherry,fyna) mbpa fynamCherry Danio rerio 1 3
Tg(mbpa:mCherry-2A-Cre-ERT2) mbpa 2ACreERT2mCherry Danio rerio 2 1
Tg(mbpa:mCherry-CAAX) mbpa CAAXmCherry Danio rerio 1 5
tg(mbpa:mcherry-ntr) mbpa mCherryNTR Danio rerio 1 1
tg(mbpa:mcitrine) mbpa Citrine Danio rerio 1 1
tg(mbpa:nls-gfp) mbpa GFPNLS Danio rerio 1 2
Tg(mbpa:NTR-EGFP) mbpa EGFPNTR Danio rerio 1 2
Tg(mbpa:TagRFP-CAAX) mbpa CAAXTagRFP Danio rerio 1 2
tg(mbpa:tagrfpt) mbpa TagRFPT Danio rerio 1 4
tg(mbpa:tagrfpt-2a-cahsa.akt1) mbpa 2ATagRFPT Danio rerioHomo sapiens 1 1
tg2(mbpa:dendra2) mbpa Dendra2 Danio rerio 1 2
tg2(mbpa:dendra2-utr) mbpa Dendra2UTR Danio rerio 1 1
tg2(mbpa:egfp-caax) mbpa CAAXEGFP Danio rerio 1 1
MARKER RELATIONSHIPS
mbpa Contained in: [BAC] CH73-207C1 (1)
mbpa Encodes: [EST] cb274 (1), fj33a07, fj33b11 (1), fq15b02 (1) (order this)
[cDNA] MGC:136630 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001020483 (1)
Genomic GenBank:CU856623 (1) 62435 nt
Select Tool
Polypeptide UniProtKB:I3ITP3 (1) 137 aa
Sequence Information (all 49)
ORTHOLOGY for mbpa ( Chr: 19 )
CITATIONS (197)