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ZIRC
ZFIN ID: ZDB-GENE-030128-2
Gene Name: myelin basic protein a
Gene Symbol: mbpa    Nomenclature History

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Previous Names: mbp, cb274 (1), fj33b11, wu:fj33b11, wu:fq15b02, zgc:136630

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to be a structural constituent of myelin sheath. Localizes to the myelin sheath and plasma membrane. Human ortholog(s) of this gene implicated in multiple sclerosis. Is expressed in EVL; nervous system; otic vesicle; periderm; and trunk. Orthologous to human MBP (myelin basic protein).
Genome Resources: Alliance (1),  Gene:326281 (1),  Ensembl(GRCz11):ENSDARG00000036186 (2)
GENE EXPRESSION
All Expression Data: 147 figures from 81 publications
Directly Submitted Expression Data: 3 figures (8 images) from Thisse et al., 2001 [cb274]
  4 figures (3 images) from Rauch et al., 2003 [fq15b02]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-mbpa
2
CRISPR2-mbpa
2
CRISPR3-mbpa
2
CRISPR4-mbpa
2
MO1-mbpa N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH mbpa HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH mbpa VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Cellular Component myelin sheath (more)
Molecular Function structural constituent of myelin sheath (more)
GO Terms (all 4)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000548 (1)
  • Pfam:PF01669 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mbpa-201 (1)    Ensembl 1719
    mbpa-202 (1)    Ensembl 1610
    mbpa-203 (1)    Ensembl 761
    mbpa-205 (1)    Ensembl 581
    mbpa-206 (1)    Ensembl 861
    mbpa-207 (1)    Ensembl 497
    mbpa-208 (1)    Ensembl 737
    mbpa-209 (1)    Ensembl 761
    mbpa-210 (1)    Ensembl 560
    mbpa-211 (1)    Ensembl 869
    ncRNA mbpa-006 (1)    Ensembl 1043
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-mbp polyclonal Rabbit IHC 34
    CONSTRUCTS WITH SEQUENCES FROM mbpa
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(1mbp:EGFP) mbpamyl7 EGFP Danio rerio 1 13
    Tg(mbp:EGFP) mbpa EGFP Danio rerio 1 14
    Tg(mbp:EGFP-CAAX) mbpa EGFP Danio rerio 1 20
    Tg(mbpa:Citrine) mbpa Citrine Danio rerio 1 1
    tg(mbpa:dendra2) mbpa Dendra2 Danio rerio 1 1
    tg(mbpa:dendra2-caax) mbpa CAAXDendra2 Danio rerio 1 1
    tg(mbpa:dendra2-utr) mbpa Dendra2UTR Danio rerio 1 1
    Tg(mbpa:EGFP-CAAX) mbpa CAAXEGFP Danio rerio 1 1
    Tg(mbpa:GAL4-VP16) mbpa GAL4VP16 Danio rerio 1 4
    Tg(mbpa:GAL4-VP16,myl7:Cerulean) mbpamyl7 CeruleanGAL4VP16 Danio rerio 1 2
    Tg(mbpa:KillerRed) mbpa KillerRed Danio rerio 1 1
    Tg(mbpa:MA-Cerulean) mbpa CeruleanMA Danio rerio 1 1
    Tg(mbpa:mCherry,cafyna) mbpa fynamCherry Danio rerio 1 3
    Tg(mbpa:mCherry,fyna) mbpa fynamCherry Danio rerio 1 3
    Tg(mbpa:mCherry-2A-Cre-ERT2) mbpa 2ACreERT2mCherry Danio rerio 2 1
    Tg(mbpa:mCherry-CAAX) mbpa CAAXmCherry Danio rerio 1 5
    Tg(mbpa:NTR-EGFP) mbpa EGFPNTR Danio rerio 1 2
    Tg(mbpa:TagRFP-CAAX) mbpa CAAXTagRFP Danio rerio 1 1
    tg(mbpa:tagrfpt) mbpa TagRFPT Danio rerio 1 3
    tg(mbpa:tagrfpt-2a-cahsa.akt1) mbpa 2ATagRFPT Danio rerioHomo sapiens 1 1
    tg2(mbpa:dendra2) mbpa Dendra2 Danio rerio 1 1
    tg2(mbpa:dendra2-utr) mbpa Dendra2UTR Danio rerio 1 1
    MARKER RELATIONSHIPS
    mbpa Contained in: [BAC] CH73-207C1 (1) (order this)
    mbpa Encodes: [EST] cb274 (1), fj33a07, fj33b11 (1), fq15b02 (1) (order this)
    [cDNA] MGC:136630 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001020483 (1)
    Genomic GenBank:CU856623 (1) 62435 bp
    Select Tool
    Polypeptide UniProtKB:I3ITP3 (1) 137 aa
    Sequence Clusters UniGene:159303 (1)
    Sequence Information (all 51)
    ORTHOLOGY for mbpa ( Chr: 19 )
    CITATIONS (178)