Gene

mcm5

ID
ZDB-GENE-021209-1
Name
minichromosome maintenance complex component 5
Symbol
mcm5 Nomenclature History
Previous Names
  • MCM5 minichromosome maintenance deficient 5
  • wu:fb34a06 (1)
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to contribute to 3'-5' DNA helicase activity and single-stranded DNA helicase activity. Involved in chordate embryonic development; mitotic cell cycle; and negative regulation of apoptotic process. Predicted to localize to MCM complex and nucleus. Is expressed in several structures, including endoderm; head; nervous system; pronephric duct; and tail bud. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 8. Orthologous to human MCM5 (minichromosome maintenance complex component 5).
Genome Resources
Note
None
Expression
All Expression Data
28 figures from 15 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mcm5 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Meier-Gorlin syndrome 8 Alliance ?Meier-Gorlin syndrome 8 617564
Associated With mcm5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018525 Mini-chromosome maintenance, conserved site
Domain IPR001208 MCM domain
Domain IPR027925 MCM N-terminal domain
Domain IPR033762 MCM OB domain
Domain IPR041562 MCM, AAA-lid domain
Family IPR008048 DNA replication licensing factor Mcm5
Family IPR031327 Mini-chromosome maintenance protein
Homologous_superfamily IPR012340 Nucleic acid-binding, OB-fold
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length DNA replication licensing factor Mcm5 MCM, AAA-lid domain MCM domain MCM N-terminal domain MCM OB domain Mini-chromosome maintenance, conserved site Mini-chromosome maintenance protein Nucleic acid-binding, OB-fold P-loop containing nucleoside triphosphate hydrolase
UniProtKB:Q6NV07 736
UniProtKB:Q7ZTS7 736
UniProtKB:F1QK71 736
UniProtKB:Q8JH75 716
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-mcm5 polyclonal Rabbit
  • IHC
12
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations