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ZIRC
ZFIN ID: ZDB-GENE-021206-1
Gene Name: heat shock 60 protein 1
Gene Symbol: hspd1    Nomenclature History

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Previous Names: hsp60 (1), cb863 (1), cpn60 (1), fa04a05, fb22d10, fi27b05, id:ibd2197, nbl (1), no blastema (1), sb:cb144 (1), wu:fa04a05, wu:fb22d10, wu:fi04a12, wu:fi27b05

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have unfolded protein binding activity. Involved in fin regeneration; regulation of cell population proliferation; and regulation of neutrophil chemotaxis. Localizes to the mitochondrial matrix. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autistic disorder; glucose intolerance; hereditary spastic paraplegia (multiple); and hypomyelinating leukodystrophy 4. Is expressed in several structures, including anterior neural keel; digestive system; mesoderm; musculature system; and nervous system. Orthologous to human HSPD1 (heat shock protein family D (Hsp60) member 1).
Genome Resources: Alliance (1),  Gene:282676 (1),  Ensembl(GRCz11):ENSDARG00000056160 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la026911Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11157 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zp7 Point Mutation Unknown Missense ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-hspd1
    2
    MO1-hspd1 N/A 1
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH hspd1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hereditary spastic paraplegia 13 Alliance Spastic paraplegia 13, autosomal dominant 605280
    hypomyelinating leukodystrophy 4 Alliance Leukodystrophy, hypomyelinating, 4 612233
    DISEASE ASSOCIATED WITH hspd1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process fin regeneration (more)
    Cellular Component mitochondrial matrix (more)
    Molecular Function ATP binding (more)
    GO Terms (all 13)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hspd1-201 (1)    Ensembl 2796
    hspd1-202 (1)    Ensembl 2249
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hspd1 No data available
    MARKER RELATIONSHIPS
    hspd1 Contained in: [BAC] DKEY-83M22 (1) (order this)
    hspd1 Contains: [SNP] rs3728228 (1)
    hspd1 Encodes: [EST] cb144 (2) (order this), cb863 (1) (order this), fa04a05, fb22d10, fi04a12, fi27b05, ibd2197 (order this)
    [cDNA] MGC:55967 (1) (order this), MGC:85875 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_181330 (1) 2739 bp
    Genomic GenBank:BX530407 (1) 292409 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q803B0 (1) 575 aa
    Sequence Clusters UniGene:75320 (1)
    Sequence Information (all 29)
    ORTHOLOGY for hspd1 ( Chr: 9 )
    CITATIONS (61)