ZFIN ID: ZDB-GENE-021115-9
Gene Name: Kruppel-like factor 6a
Gene Symbol: klf6a    Nomenclature History

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Previous Names: klf6, cb538 (1), copeb, wu:fb76d04 (1), wu:fb92h03 (1), wu:fe26g06 (1), wu:fk78f12 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific; chromatin binding activity; and enhancer sequence-specific DNA binding activity. Involved in several processes, including animal organ development; optic nerve formation; and regulation of hematopoietic stem cell proliferation. Localizes to the chromatin. Human ortholog(s) of this gene implicated in prostate cancer. Is expressed in several structures, including cardiovascular system; digestive system; intermediate cell mass of mesoderm; nervous system; and pleuroperitoneal region. Orthologous to human KLF6 (Kruppel like factor 6).
Genome Resources: Alliance (1),  Gene:280650 (1),  Ensembl(GRCz11):ENSDARG00000029072 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ioz102 Small Deletion Exon 1 Premature Stop CRISPR
sa6755 Point Mutation Unknown Splice Site ENU
sa32473 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-klf6a 1
    MO1-klf6a N/A 4
    MO2-klf6a N/A 2
    MO3-klf6a N/A 1
    MO4-klf6a N/A 1
    DISEASE ASSOCIATED WITH klf6a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    prostate cancer Alliance Prostate cancer, somatic 176807
    stomach cancer Alliance Gastric cancer, somatic 613659
    DISEASE ASSOCIATED WITH klf6a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process optic nerve formation (more)
    Cellular Component chromatin (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR013087 Zinc finger C2H2-type
    Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA klf6a-202 (1)    Ensembl 3369
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-klf6a polyclonal IgG Rabbit WB Santa Cruz Biotechnology, Inc.
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM klf6a No data available
    MARKER RELATIONSHIPS
    klf6a Contained in: [BAC] CH73-36I7 (1)
    klf6a Encodes: [EST] cb538 (1) (order this), fb76d04, fb92h03, fe26g06, fk78f12
    [cDNA] MGC:55837 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_201461 (1) 3046 bp
    Genomic GenBank:CR376788 (1) 188521 bp
    Select Tool
    Polypeptide UniProtKB:F1R7F0 (1) 283 aa
    Sequence Information (all 22)
    ORTHOLOGY for klf6a ( Chr: 24 )
    CITATIONS (34)