Gene

klf6a

ID
ZDB-GENE-021115-9
Name
Kruppel-like factor 6a
Symbol
klf6a Nomenclature History
Previous Names
  • klf6
  • cb538 (1)
  • copeb
  • wu:fb76d04 (1)
  • wu:fb92h03 (1)
  • wu:fe26g06 (1)
  • wu:fk78f12 (1)
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific; chromatin binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; optic nerve formation; and regulation of hematopoietic stem cell proliferation. Localizes to chromatin. Is expressed in several structures, including cardiovascular system; digestive system; intermediate cell mass of mesoderm; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human KLF6 (Kruppel like factor 6).
Genome Resources
Note
None
Expression
All Expression Data
16 figures from 7 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With klf6a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
prostate cancer Alliance Prostate cancer, somatic 176807
stomach cancer Alliance Gastric cancer, somatic 613659
Associated With klf6a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013087 Zinc finger C2H2-type
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:F1R7F0 283
UniProtKB:E9QDL1 274
UniProtKB:Q7ZUK3 283
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-klf6a polyclonal IgG Rabbit
  • WB
Santa Cruz Biotechnology, Inc.
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations