ZFIN ID: ZDB-GENE-021015-3
Gene Name: STT3 oligosaccharyltransferase complex catalytic subunit A
Gene Symbol: stt3a    Nomenclature History

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Previous Names: cb437 (1), itm1, wu:fb38c11

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have dolichyl-diphosphooligosaccharide-protein glycotransferase activity. Predicted to be involved in post-translational protein modification and protein N-linked glycosylation via asparagine. Predicted to localize to integral component of membrane. Is expressed in axial mesoderm; hatching gland; musculature system; notochord; and otic placode. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Iw. Orthologous to human STT3A (STT3 oligosaccharyltransferase complex catalytic subunit A).
Genome Resources: Alliance (1),  Gene:266797 (1),  Ensembl(GRCz11):ENSDARG00000104953 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2001 [cb437]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7143563]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la017566Tg Transgenic Insertion Unknown Unknown DNA
sa17071 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21794 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH stt3a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital disorder of glycosylation Iw Alliance Congenital disorder of glycosylation, type Iw 615596
    DISEASE ASSOCIATED WITH stt3a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein glycosylation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function dolichyl-diphosphooligosaccharide-protein glycotransferase activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA stt3a-201 (1)    Ensembl 2071
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM stt3a No data available
    MARKER RELATIONSHIPS
    stt3a Contained in: [Fosmid] CH1073-74N1 (1)
    stt3a Encodes: [EST] cb437 (1) (order this), fb38c11 (1), IMAGE:7143563 (1)
    [cDNA] MGC:56322 (1), MGC:77796 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201458 (1) 2608 nt
    Genomic GenBank:CU633886 (1) 32822 nt
    Select Tool
    Polypeptide UniProtKB:Q7ZUY9 (1) 705 aa
    Sequence Information (all 20)
    ORTHOLOGY for stt3a ( Chr: 10 )
    CITATIONS (29)