ZFIN ID: ZDB-GENE-020709-1
Gene Name: myosin VIIAa
Gene Symbol: myo7aa

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Previous Names: myo7a, mar, mariner

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(Including Attributions)
Location: Chr: 18 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 8 figures from 5 publications
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  anterior crista, anterior lateral line neuromast, anterior macula, brain (all 20) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa11378 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16521 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23224 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa28973 Point Mutation Unknown Splice Site ENU
    sa28974 Point Mutation Unknown Premature Stop ENU
    sa36565 Point Mutation Unknown Splice Site ENU
    sa36566 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa39188 Point Mutation Unknown Premature Stop ENU
    tc320b Point Mutation Unknown Premature Stop
  • European Zebrafish Resource Center (EZRC) (order this)
  • tn3540 Point Mutation Unknown Missense
  • European Zebrafish Resource Center (EZRC) (order this)
  • tn4503 Point Mutation Unknown Premature Stop
    tr202 Point Mutation Unknown Missense
  • European Zebrafish Resource Center (EZRC) (order this)
  • ty220 Point Mutation Unknown Premature Stop
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: CRISPR1-myo7aa (1), CRISPR2-myo7aa (2), CRISPR3-myo7aa (2)
    PHENOTYPE
    Data: 10 figures from 5 publications
    Observed in: anterior macula stereocilium bundle, auditory receptor cell stereocilium bundle, behavior, detection of light stimulus involved in visual perception (all 15) expand
    DISEASE ASSOCIATED WITH myo7aa HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    autosomal dominant nonsyndromic deafness 11 Deafness, autosomal dominant 11 601317
    autosomal recessive nonsyndromic deafness 2 Deafness, autosomal recessive 2 600060
    Usher syndrome type 1 Usher syndrome, type 1B 276900
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process detection of mechanical stimulus involved in sensory perception (more)
    Cellular Component cytoskeleton (more)
    Molecular Function ATP binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000048 (1)
  • InterPro:IPR000299 (1)
  • InterPro:IPR000857 (1)
  • InterPro:IPR001452 (1)
  • InterPro:IPR001609 (1)
  • InterPro:IPR011993 (1)
  • InterPro:IPR014352 (1)
  • InterPro:IPR019748 (1)
  • InterPro:IPR019749 (1)
  • InterPro:IPR027417 (1)
  • InterPro:IPR029071 (1)
  • PROSITE:PS50002 (1)
  • PROSITE:PS50057 (1)
  • PROSITE:PS50096 (1)
  • PROSITE:PS51016 (1)
  • PROSITE:PS51456 (1)
  • Pfam:PF00063 (1)
  • Pfam:PF00373 (1)
  • Pfam:PF00612 (1)
  • Pfam:PF00784 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA myo7aa-001 (1) 7447
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIES
    ab1-myo7aa (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM myo7aa
    Tg(myo7aa-gata2a:EGFP), Tg(myo7aa-gata2a:mCherry), Tg(myo7aa-gata2a:mCherry-myo7aa), Tg2(myo7aa-gata2a:EGFP), Tg3(myo7aa-gata2a:EGFP) (all 10) expand
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    myo7aaContained in: [BAC] CH211-135H6 (1) (order this)
    myo7aaEncodes: [cDNA] MGC:195128 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_152983 (1) 7590bp
    Genomic GenBank:CU459145 (1) 196166bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IM58 (1) 2183aa
    Sequence Clusters UniGene:82508 (1)
    Sequence Information (all 18)
    OTHER myo7aa GENE PAGES
  • Gene:252846 (1)
  • VEGA:OTTDARG00000032417 (1)
  • Ensembl(GRCz10):ENSDARG00000099871 (1)
  • ORTHOLOGY for myo7aa (Chr: 18)
    CITATIONS (38)