ZFIN ID: ZDB-GENE-020507-3
Gene Name: VANGL planar cell polarity protein 2
Gene Symbol: vangl2
Sequence Ontology ID : SO:0000704

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Previous Names: stbm (1), strabismus (1), tri, trilobite

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(Including Attributions)
Location: Chr: 7 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Involved in several processes, including embryonic morphogenesis, morphogenesis of an epithelium, and nervous system development; localizes to the plasma membrane; used to study ciliopathy;  ...
GENE EXPRESSION
All Expression Data: 8 figures from 8 publications
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Larval:Day 6 (144.0h-168.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la026205Tg Transgenic Insertion Unknown Unknown DNA
la026206Tg Transgenic Insertion Unknown Unknown DNA
m144 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m209 Insertion Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m747 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m778 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • rw75 Unknown Unknown Unknown
    sa12076 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18862 Point Mutation Unknown Premature Stop ENU
    tc240 Insertion Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tk50f Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • vangl2_unspecified Unspecified Unknown Unknown
    vu67 Point Mutation Unknown Premature Stop
    vu64 Unknown Unknown Unknown ENU
    Targeting reagents:
    PHENOTYPE
    Data: 80 figures from 43 publications
    Observed in:
    DISEASE ASSOCIATED WITH vangl2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Neural tube defects 182940
    DISEASE ASSOCIATED WITH vangl2 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    ciliopathy WT + MO1-vangl2 standard conditions Leightner et al., 2013
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process convergent extension (more)
    Cellular Component plasma membrane (more)
    Molecular Function protein binding (more)
    GO Terms (all 44)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR009539 (1)
  • Pfam:PF06638 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA vangl2-201 (1) 5862
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM vangl2
    MARKER RELATIONSHIPS
    vangl2Encodes: [cDNA] MGC:76845 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_153674 (1) 2100bp
    Genomic GenBank:CABZ01078579 (1) 13804bp
    Polypeptide UniProtKB:Q8UVJ6 (1) 526aa
    Sequence Clusters UniGene:91583 (1)
    Sequence Information (all 14)
    OTHER vangl2 GENE PAGES
  • Alliance (1)
  • Gene:245949 (1)
  • VEGA:OTTDARG00000043429 (1)
  • Ensembl(GRCz11):ENSDARG00000027397 (2)
  • ORTHOLOGY for vangl2 (Chr: 7)
    CITATIONS (128)