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ZIRC
ZFIN ID: ZDB-GENE-020507-3
Gene Name: VANGL planar cell polarity protein 2
Gene Symbol: vangl2    Nomenclature History

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Previous Names: stbm (1), strabismus (1), tri, trilobite

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Involved in several processes, including embryonic morphogenesis; nervous system development; and regulation of Wnt signaling pathway. Localizes to the plasma membrane. Used to study ciliopathy. Human ortholog(s) of this gene implicated in neural tube defect. Is expressed in central nervous system; liver; pharyngeal arch; and sensory system. Orthologous to human VANGL2 (VANGL planar cell polarity protein 2).
Genome Resources: Alliance (1),  Gene:245949 (1),  Ensembl(GRCz11):ENSDARG00000027397 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la026205Tg Transgenic Insertion Unknown Unknown DNA
la026206Tg Transgenic Insertion Unknown Unknown DNA
m144 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m209 Insertion Unknown Frameshift, Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m747 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m778 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • rw75 Unknown Unknown Unknown
    sa12076 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18862 Point Mutation Unknown Premature Stop ENU
    tc240 Insertion Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tk50f Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • vangl2_unspecified Unspecified Unknown Unknown
    vu64 Unknown Unknown Unknown ENU
    vu67 Point Mutation Unknown Premature Stop
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-vangl2
    1
    CRISPR2-vangl2
    1
    MO1-vangl2 N/A 28
    MO2-vangl2 N/A 1
    MO3-vangl2 N/A 2
    MO4-vangl2 N/A 3
    PHENOTYPE
    Data: 87 figures from 45 publications
    Observed in:
    DISEASE ASSOCIATED WITH vangl2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Neural tube defects 182940
    DISEASE ASSOCIATED WITH vangl2 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    ciliopathy WT + MO1-vangl2 standard conditions Leightner et al., 2013
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process convergent extension (more)
    Cellular Component plasma membrane (more)
    Molecular Function protein binding (more)
    GO Terms (all 44)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR009539 (1)
  • Pfam:PF06638 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA vangl2-201 (1)    Ensembl 5862
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-vangl2 polyclonal IgG Goat Santa Cruz Biotechnology, Inc.
    2
    CONSTRUCTS WITH SEQUENCES FROM vangl2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(10XUAS:GFP-vangl2) UAS GFPvangl2 Danio rerio 1 1
    Tg(myo6b:RFP-vangl2) myo6b RFPvangl2 Danio rerio 1 2
    Tg(UAS:MYC-vangl2) UAS vangl2 Danio rerio 1 3
    Tg(UAS:MYC-vangl2-Dme.Vang,NLS-RFP,myl7:EGFP) myl7UAS EGFPMYCNLSRFPvangl2 Danio rerioDrosophila melanogaster 1 2
    Tg(UAS:MYC-vangl2-Hsa.PLCD1,NLS-RFP,myl7:EGFP) myl7UAS EGFPMYCNLSRFPvangl2 Danio rerioHomo sapiens 1 2
    Tg(UAS:MYC-vangl2-Mmu.Lyn,NLS-RFP,myl7:EGFP) myl7UAS EGFPMYCNLSRFPvangl2 Danio rerioMus musculus 1 2
    Tg(UAS:MYC-vangl2-Rno.P2rx2,NLS-RFP,myl7:EGFP) myl7UAS EGFPMYCNLSRFPvangl2 Danio rerioRattus norvegicus 1 2
    Tg(vangl2:EGFP-vangl2) vangl2 EGFPvangl2 Danio rerio 1 5
    Tg1(UAS:MYC-vangl2,NLS-RFP,myl7:EGFP) myl7UAS EGFPMYCNLSRFPvangl2 Danio rerio 1 2
    Tg1(UAS:vangl2-MYC,NLS-RFP,myl7:EGFP) myl7UAS EGFPMYCNLSRFPvangl2 Danio rerio 1 2
    Tg2(UAS:MYC-vangl2,NLS-RFP,myl7:EGFP) myl7UAS EGFPMYCNLSRFPvangl2 Danio rerio 1 2
    Tg2(UAS:vangl2-MYC,NLS-RFP,myl7:EGFP) myl7UAS EGFPMYCNLSRFPvangl2 Danio rerio 1 2
    Tg3(UAS:MYC-vangl2,NLS-RFP,myl7:EGFP) myl7UAS EGFPMYCNLSRFPvangl2 Danio rerio 1 2
    Tg4(UAS:MYC-vangl2,NLS-RFP,myl7:EGFP) myl7UAS EGFPMYCNLSRFPvangl2 Danio rerio 1 2
    MARKER RELATIONSHIPS
    vangl2 Encodes: [cDNA] MGC:76845 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_153674 (1) 2100 bp
    Genomic GenBank:CABZ01078579 (1) 13804 bp
    Polypeptide UniProtKB:Q8UVJ6 (1) 526 aa
    Sequence Clusters UniGene:91583 (1)
    Sequence Information (all 14)
    ORTHOLOGY for vangl2 ( Chr: 7 )
    CITATIONS (130)