ZFIN Fish: WT + MO1-vangl2

ZFIN ID: ZDB-FISH-150901-2784

ZFIN ID: ZDB-FISH-150901-2784

Fish name:	WT + MO1-vangl2
Genotype:	WT
Targeting Reagent:	MO1-vangl2

HUMAN DISEASE MODELED by WT + MO1-vangl2

Human Disease	Conditions	Citations
ciliopathy	standard conditions	Leightner et al., 2013

GENE EXPRESSION
Gene expression in WT + MO1-vangl2

RNA expression

Expressed Gene	Structure	Conditions	Figures
ctslb	polster	standard conditions	Fig. 2 from Young et al., 2014
dlx3b	neural plate preplacodal ectoderm	standard conditions	Fig. 2 from Young et al., 2014 Fig. 10 from Harrington et al., 2007
egr2b	hindbrain neural keel	standard conditions	Fig. S2 from Jessen et al., 2002
emx1	telencephalon	standard conditions	Fig. S2 from Jessen et al., 2002
gsc	margin dorsal region	standard conditions	Fig. 8 from Angonin et al., 2013
isl1a	primary motor neuron primary neuron	standard conditions	Fig. 7 from Takamiya et al., 2006
myod1	somite	standard conditions	Fig. 1 from Reynolds et al., 2010 Fig. 10 from Harrington et al., 2007 Fig. S2 from Jessen et al., 2002
pax2b	midbrain hindbrain boundary	standard conditions	Fig. S2 from Jessen et al., 2002
pcdh8	paraxial mesoderm	standard conditions	Fig. 10 from Harrington et al., 2007
tbxta	notochord	standard conditions	Fig. 2 from Young et al., 2014 Fig. 10 from Harrington et al., 2007
zic1	forebrain neural rod	standard conditions	Fig. S2 from Jessen et al., 2002

Protein expression No data available

Reporter gene expression No data available

PHENOTYPE
Phenotype in WT + MO1-vangl2

Phenotype	Conditions	Figures
cilium movement decreased frequency, abnormal	standard conditions	Fig. 9 from Leightner et al., 2013
convergent extension involved in axis elongation disrupted, abnormal	standard conditions	Fig. 2 from Reynolds et al., 2010 Fig. 5 from Waxman et al., 2004
convergent extension involved in gastrulation disrupted, abnormal	standard conditions	Fig. 4 from Li et al., 2011
convergent extension involved in gastrulation process quality, abnormal	standard conditions	Fig. 4 from Burcklé et al., 2011
ectoderm cell orientation ectoderm, abnormal	standard conditions	Fig. 3 from Young et al., 2014
ectoderm cell shape, abnormal	standard conditions	Fig. 3 from Young et al., 2014
establishment of cell polarity disrupted, abnormal	standard conditions	Fig. 3 from Li et al., 2011
eye decreased distance eye, abnormal	standard conditions	Fig. 5 from Waxman et al., 2004
eye decreased width, abnormal	standard conditions	Fig. 5 from Waxman et al., 2004
head hydrocephalic, abnormal	standard conditions	Fig. 9 from Leightner et al., 2013
neural plate increased width, abnormal	standard conditions	Fig. 6 from Ferrante et al., 2009
neural plate width, normal	standard conditions	Fig. 10 from Harrington et al., 2007
notochord decreased length, abnormal	standard conditions	Fig. S1 from Nambiar et al., 2007
notochord increased width, abnormal	standard conditions	Fig. 3 from Li et al., 2011
notochord undulate, abnormal	standard conditions	Fig. 2 , Fig. 3 from Li et al., 2011
notochord width, normal	standard conditions	Fig. 10 from Harrington et al., 2007
notochord cell orientation notochord, abnormal	standard conditions	Fig. 3 from Young et al., 2014
notochord cell shape, abnormal	standard conditions	Fig. 3 from Young et al., 2014
paraxial mesoderm increased width, abnormal	standard conditions	Fig. 10 from Harrington et al., 2007
post-vent region morphology, normal	standard conditions	Fig. 8 from Harrington et al., 2007
pronephric duct cilium decreased functionality, abnormal	standard conditions	Fig. 9 from Leightner et al., 2013
pronephric duct cilium disorganized, abnormal	standard conditions	Fig. 9 from Leightner et al., 2013
pronephros cystic, abnormal	standard conditions	Fig. 9 from Leightner et al., 2013
somite condensed, abnormal	standard conditions	Fig. S1 from Nambiar et al., 2007
somite flat, abnormal	standard conditions	Fig. 5 from Waxman et al., 2004
somite increased width, abnormal	standard conditions	Fig. 2 from Li et al., 2011 Fig. 2 from Reynolds et al., 2010 Fig. 10 from Harrington et al., 2007
trunk decreased length, abnormal	standard conditions	Fig. 1 , Fig. 2 from Reynolds et al., 2010
whole organism decreased length, abnormal	standard conditions	Fig. 2 from Li et al., 2011 Fig. 6 from Ferrante et al., 2009 Fig. 5 from Waxman et al., 2004
whole organism increased curvature, abnormal	standard conditions	Fig. 9 from Leightner et al., 2013
whole organism morphology, abnormal	standard conditions	Fig. 2 from Young et al., 2014
whole organism anterior-posterior axis decreased length, abnormal	standard conditions	Fig. 1 from Reynolds et al., 2010 Fig. 1 from Jessen et al., 2002

CITATIONS (13)