ZFIN ID: ZDB-GENE-020129-1
Gene Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Gene Symbol: cacna1c
Previous Names: C-LTCC (1), isl, island beat, ZfCav1.2 (1)
Location: Chr: 4 Mapping Details/Browsers
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  central nervous system, ceratohyal cartilage, gut, lateral plate mesoderm (all 8) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la015364Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m231 Unknown Unknown Unknown ENU
    m379 Point Mutation Unknown Premature Stop ENU
    m458 Point Mutation Unknown Premature Stop ENU
    sa10930 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa15296 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40287 Point Mutation Unknown Unknown ENU
    Targeting reagents: MO1-cacna1c (1), MO2-cacna1c (1), MO3-cacna1c (1)
    PHENOTYPE
    Data: 17 figures from 8 publications
    Observed in: anatomical system, atrial myocardium, blood circulation, brain (all 23) expand
    DISEASE ASSOCIATED WITH cacna1c HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Brugada syndrome Brugada syndrome 3 611875
    long QT syndrome Timothy syndrome 601005
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process calcium ion import (more)
    Cellular Component voltage-gated calcium channel complex (more)
    Molecular Function voltage-gated calcium channel activity (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002077 (1)
  • InterPro:IPR005446 (1)
  • InterPro:IPR005451 (1)
  • InterPro:IPR005821 (1)
  • InterPro:IPR014873 (1)
  • InterPro:IPR027359 (1)
  • InterPro:IPR031649 (1)
  • InterPro:IPR031688 (1)
  • Pfam:PF00520 (1)
  • Pfam:PF08763 (1)
  • Pfam:PF16885 (1)
  • Pfam:PF16905 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA cacna1c-001 (1) 6852
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM cacna1c No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    cacna1cContained in: [BAC] CH211-87P6 (1) (order this), DKEY-65M5 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131900 (1) 6776bp
    Genomic GenBank:BX248410 (1) 250665bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q5TZF1 (1) 2196aa
    Sequence Clusters UniGene:83683 (1)
    Sequence Information (all 30)
    OTHER cacna1c GENE PAGES
  • Gene:170581 (1)
  • VEGA:OTTDARG00000008481 (1)
  • Ensembl(GRCz10):ENSDARG00000008398 (1)
  • ORTHOLOGY for cacna1c (Chr: 4)
    Species Symbol Chromosome Accession # Evidence
    Human CACNA1C 12
  • Gene:775
  • OMIM:114205
  • HGNC:1390
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Mouse Cacna1c 6
  • MGI:103013
  • Gene:12288
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (37)