Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-020129-1
Gene Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Gene Symbol: cacna1c
Previous Names: C-LTCC (1), ZfCav1.2 (1), isl, island beat
Location: Chr: 4   Details
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  central nervous system, ceratohyal cartilage, gut, lateral plate mesoderm (all 8) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 8 genotypes
Alleles: la015364Tg, m231, m379, m458, sa10930 (all 6) expand
Knockdown reagents: MO1-cacna1c (1), MO2-cacna1c (1)
PHENOTYPE
Data: 12 figures from 5 publications
Observed in: anatomical system, atrial myocardium, blood circulation, brain (all 19) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Brugada syndrome 3 611875
Timothy syndrome 601005
GENE ONTOLOGY
Ontology GO Term
Biological Process calcium ion import (more)
Cellular Component voltage-gated calcium channel complex (more)
Molecular Function voltage-gated calcium channel activity (more)
GO Terms (all 20)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002077 (1)
  • InterPro:IPR005446 (1)
  • InterPro:IPR005451 (1)
  • InterPro:IPR005821 (1)
  • InterPro:IPR014873 (1)
  • InterPro:IPR027359 (1)
  • Pfam:PF00520 (1)
  • Pfam:PF08763 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA cacna1c-001 (1) 6852
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cacna1c No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    cacna1c Contained in: [BAC] CH211-87P6 (1) (order this), DKEY-65M5 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131900 (1) 6776 bp
    Genomic GenBank:BX248410 (1) 250665 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q5TZF1 (1) 2196 aa
    Sequence Clusters UniGene:83683 (1)
    Sequence Information (all 30)
    OTHER cacna1c GENE PAGES
  • Gene:170581 (1)
  • VEGA:OTTDARG00000008481 (1)
  • Ensembl(Zv9):ENSDARG00000008398 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish cacna1c 4  
    Human CACNA1C 12 (12p13.3)
  • OMIM:114205
  • Gene:775
  • Mouse Cacna1c 6 ( 55.86 cM)
  • MGI:103013
  • Gene:12288
  • Orthology Details
    CITATIONS (31)