ZFIN ID: ZDB-GENE-020129-1
Gene Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Gene Symbol: cacna1c    Nomenclature History

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Previous Names: C-LTCC (1), isl, island beat, ZfCav1.2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Exhibits voltage-gated calcium channel activity. Involved in animal organ development; calcium ion import; and regulation of heart contraction. Predicted to localize to voltage-gated calcium channel complex. Is expressed in central nervous system; digestive system; lateral plate mesoderm; pericardial region; and splanchnocranium. Human ortholog(s) of this gene implicated in Brugada syndrome 3 and Timothy syndrome. Orthologous to human CACNA1C (calcium voltage-gated channel subunit alpha1 C).
Genome Resources: Alliance (1),  Gene:170581 (1),  Ensembl(GRCz11):ENSDARG00000008398 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a366 Indel Unknown Unknown
la015364Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m231 Unknown Unknown Unknown ENU
    m379 Point Mutation Unknown Premature Stop ENU
    m458 Point Mutation Unknown Premature Stop ENU
    sa6050 Point Mutation Unknown Splice Site ENU
    sa6943 Point Mutation Unknown Splice Site ENU
    sa10930 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15296 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38439 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40287 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44588 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cacna1c 1
    CRISPR2-cacna1c 1
    CRISPR3-cacna1c 1
    CRISPR4-cacna1c 1
    MO1-cacna1c N/A 2
    MO2-cacna1c N/A 1
    MO3-cacna1c N/A 2
    DISEASE ASSOCIATED WITH cacna1c HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Brugada syndrome 3 Alliance Brugada syndrome 3 611875
    Timothy syndrome Alliance Timothy syndrome 601005
    Long QT syndrome 8 618447
    DISEASE ASSOCIATED WITH cacna1c VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process calcium ion import (more)
    Cellular Component voltage-gated calcium channel complex (more)
    Molecular Function voltage-gated calcium channel activity (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cacna1c-202 (1)    Ensembl 6852
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cacna1c No data available
    MARKER RELATIONSHIPS
    cacna1c Contained in: [BAC] CH211-87P6 (1), DKEY-65M5 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131900 (1) 6776 nt
    Genomic GenBank:BX248410 (1) 250665 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q5TZF1 (1) 2196 aa
    Sequence Information (all 50)
    ORTHOLOGY for cacna1c ( Chr: 4 )
    CITATIONS (56)