ZFIN ID: ZDB-GENE-020129-1
Gene Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Gene Symbol: cacna1c
Previous Names: C-LTCC (1), isl, island beat, ZfCav1.2 (1)
Location: Chr: 4 Mapping Details/Browsers
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  central nervous system, ceratohyal cartilage, gut, lateral plate mesoderm (all 8) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS 
Allele Type Mutagen Suppliers
la015364Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m231 Unknown ENU
    m379 Point Mutation ENU
    m458 Point Mutation ENU
    sa10930 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa15296 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: MO1-cacna1c (1), MO2-cacna1c (1), MO3-cacna1c (1)
    PHENOTYPE
    Data: 17 figures from 8 publications
    Observed in: anatomical system, atrial myocardium, blood circulation, brain (all 23) expand
    DISEASE ASSOCIATED WITH cacna1c HUMAN ORTHOLOG 
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Brugada syndrome Brugada syndrome 3 611875
    long QT syndrome Timothy syndrome 601005
    GENE ONTOLOGY 
    Ontology GO Term
    Biological Process calcium ion import (more)
    Cellular Component voltage-gated calcium channel complex (more)
    Molecular Function voltage-gated calcium channel activity (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002077 (1)
  • InterPro:IPR005446 (1)
  • InterPro:IPR005451 (1)
  • InterPro:IPR005821 (1)
  • InterPro:IPR014873 (1)
  • InterPro:IPR027359 (1)
  • InterPro:IPR031649 (1)
  • InterPro:IPR031688 (1)
  • Pfam:PF00520 (1)
  • Pfam:PF08763 (1)
  • Pfam:PF16885 (1)
  • Pfam:PF16905 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA cacna1c-001 (1) 6852
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cacna1c No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS 
    cacna1cContained in: [BAC] CH211-87P6 (1) (order this), DKEY-65M5 (1) (order this)
    SEQUENCE INFORMATION 
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131900 (1) 6776bp
    Genomic GenBank:BX248410 (1) 250665bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q5TZF1 (1) 2196aa
    Sequence Clusters UniGene:83683 (1)
    Sequence Information (all 30)
    OTHER cacna1c GENE PAGES 
  • Gene:170581 (1)
  • VEGA:OTTDARG00000008481 (1)
  • Ensembl(GRCz10):ENSDARG00000008398 (1)
  • ORTHOLOGY for cacna1c (Chr: 4) 
    Species Symbol Chromosome Accession # Evidence
    Human CACNA1C 12
  • Gene:775
  • OMIM:114205
  • HGNC:1390
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Mouse Cacna1c 6
  • MGI:103013
  • Gene:12288
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (36)