ZFIN ID: ZDB-GENE-020108-1
Gene Name: prosaposin
Gene Symbol: psap    Nomenclature History

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Previous Names: cb759 (1), wu:fa14a06, wu:fb36e02, wu:fb58g07 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; regulation of lipid metabolic process; and sphingolipid metabolic process. Predicted to localize to extracellular space. Is expressed in blood; extension; peripheral olfactory organ; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in atypical Gaucher's disease due to saposin c deficiency and combined saposin deficiency. Orthologous to several human genes including PSAP (prosaposin).
Genome Resources: Alliance (1),  Gene:140811 (1),  Ensembl(GRCz11):ENSDARG00000013968 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 3 publications
Directly Submitted Expression Data: 6 figures (14 images) from Thisse et al., 2001 [cb759]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Day 4 (96.0h-120.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa18635 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42131 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH psap HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    atypical Gaucher's disease due to saposin c deficiency Alliance Gaucher disease, atypical 610539
    combined saposin deficiency Alliance Combined SAP deficiency 611721
    metachromatic leukodystrophy Alliance Metachromatic leukodystrophy due to SAP-b deficiency 249900
    Krabbe disease, atypical 611722
    DISEASE ASSOCIATED WITH psap VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (more)
    Cellular Component lysosome (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA psap-201 (1)    Ensembl 2409
    psap-203 (1)    Ensembl 496
    psap-204 (1)    Ensembl 623
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM psap No data available
    MARKER RELATIONSHIPS
    psap Contained in: [BAC] CH211-199I24 (1), DKEY-37H18 (1) (order this)
    psap Contains: [SNP] rs3728529 (1), rs3728530 (1)
    psap Encodes: [EST] cb759 (1), fa14a06, fb36e02, fb58g07 (1)
    [cDNA] MGC:65941 (1), MGC:77888 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131883 (1) 2402 nt
    Genomic GenBank:CR388420 (1) 121689 nt
    Select Tool
    Polypeptide UniProtKB:E7FCT1 (1) 522 aa
    Sequence Information (all 39)
    ORTHOLOGY for psap ( Chr: 13 )
    CITATIONS (31)