ZFIN ID: ZDB-GENE-020103-1
Gene Name: iroquois homeobox 7
Gene Symbol: irx7    Nomenclature History

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Previous Names: iro7, cb263 (1), zgc:109841, ziro7 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including embryonic skeletal joint development; nervous system development; and retina morphogenesis in camera-type eye. Predicted to localize to nucleus. Is expressed in several structures, including head; interhyal-hyosymplectic joint; nervous system; neural keel; and neural plate.
Genome Resources: Alliance (1),  Gene:140746 (1),  Ensembl(GRCz11):ENSDARG00000002601 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
el538 Indel Unknown Unknown TALEN
el540 Small Deletion Unknown Unknown TALEN
nksagp011Gt Transgenic Insertion Exon 2 Unknown DNA
sa24393 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32464 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-irx7 N/A 3
    MO2-irx7 N/A 3
    MO3-irx7 N/A 3
    TALEN1-irx7 1
    DISEASE ASSOCIATED WITH irx7 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH irx7 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic skeletal joint development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA irx7-201 (1)    Ensembl 1187
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-irx7 polyclonal Rabbit WB 1
    Ab2-irx7 polyclonal Rabbit WB 1
    Ab3-irx7 polyclonal Rabbit 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM irx7
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(UAS:irx7-2A-EGFP,cryaa:Cerulean) cryaaUAS 2ACeruleanEGFPirx7 Danio rerio 1 1
    MARKER RELATIONSHIPS
    irx7 Contained in: [BAC] CH211-231H20 (1)
    irx7 Encodes: [EST] cb263 (2) (order this)
    [cDNA] MGC:109841 (1), MGC:191512 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131881 (1) 1207 nt
    Genomic GenBank:CR381544 (1) 146827 nt
    Select Tool
    Polypeptide UniProtKB:Q504I0 (1) 314 aa
    Sequence Information (all 18)
    ORTHOLOGY for irx7 ( Chr: 23 )
    CITATIONS (51)