Gene

sox10

ID
ZDB-GENE-011207-1
Name
SRY-box transcription factor 10
Symbol
sox10 Nomenclature History
Previous Names
  • sox10b (1)
  • cls
  • colorless (1)
  • colourless
  • golas (1)
  • gos (1)
  • zgc:100757
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including nervous system development; neural crest cell migration; and sensory organ development. Predicted to localize to nucleus. Is expressed in several structures, including glioblast; head; iridoblast; nervous system; and neural crest. Used to study Hirschsprung's disease and Waardenburg's syndrome. Human ortholog(s) of this gene implicated in Kallmann syndrome; PCWH syndrome; Waardenburg syndrome type 2E; and Waardenburg syndrome type 4C. Orthologous to human SOX10 (SRY-box transcription factor 10).
Genome Resources
Note
None
Expression
All Expression Data
239 figures from 156 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
65 figures from 30 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sox10 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
PCWH syndrome Alliance PCWH syndrome 609136
Waardenburg syndrome type 2E Alliance Waardenburg syndrome, type 2E, with or without neurologic involvement 611584
Waardenburg syndrome type 4C Alliance Waardenburg syndrome, type 4C 613266
Associated With sox10 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR009071 High mobility group box domain
Domain IPR022151 Sox developmental protein N-terminal
Homologous_superfamily IPR036910 High mobility group box domain superfamily
Domain Details Per Protein
Protein Length High mobility group box domain High mobility group box domain superfamily Sox developmental protein N-terminal
UniProtKB:A0PJQ1 348
UniProtKB:Q6DBW6 169
UniProtKB:Q90XD1 485
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-sox10 polyclonal Rabbit
  • IHC
10
Ab1-sox10 polyclonal Rabbit
  • IHC
39
Ab3-sox10 polyclonal IgG Rabbit
  • IHC
GeneTex
15
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations