ZFIN ID: ZDB-GENE-011207-1
Gene Name: SRY-box transcription factor 10
Gene Symbol: sox10    Nomenclature History

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Previous Names: sox10b (1), cls, colorless (1), colourless, golas (1), gos (1), zgc:100757

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including inner ear development; iridophore differentiation; and nervous system development. Predicted to localize to the nucleus. Used to study Hirschsprung's disease and Waardenburg's syndrome. Human ortholog(s) of this gene implicated in Kallmann syndrome; PCWH syndrome; Waardenburg syndrome type 2E; and Waardenburg syndrome type 4C. Is expressed in several structures, including glioblast; head; iridoblast; nervous system; and neural crest. Orthologous to human SOX10 (SRY-box transcription factor 10).
Genome Resources: Alliance (1),  Gene:140616 (1),  Ensembl(GRCz11):ENSDARG00000077467 (2)
GENE EXPRESSION
All Expression Data: 235 figures from 154 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
baz1 Point Mutation Unknown Missense ENU
m241 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m618 Point Mutation Unknown Missense ENU
    sox10_unspecified Unspecified Unknown Unknown
    t3 Insertion Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tw2 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tw11 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • utr13e1 Unknown Unknown Unknown
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-sox10
    1
    CRISPR2-sox10
    1
    CRISPR3-sox10
    1
    CRISPR4-sox10
    1
    MO1-sox10 N/A 7
    MO2-sox10 N/A 5
    MO3-sox10 N/A 2
    MO4-sox10 N/A 1
    PHENOTYPE
    Data: 63 figures from 29 publications
    Observed in:
    DISEASE ASSOCIATED WITH sox10 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    PCWH syndrome Alliance PCWH syndrome 609136
    Waardenburg syndrome type 2E Alliance Waardenburg syndrome, type 2E, with or without neurologic involvement 611584
    Waardenburg syndrome type 4C Alliance Waardenburg syndrome, type 4C 613266
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cranial skeletal system development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 29)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR009071 High mobility group box domain
    Domain IPR022151 Sox developmental protein N-terminal
    Homologous_superfamily IPR036910 High mobility group box domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sox10-201 (1)    Ensembl 3205
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-sox10 polyclonal Rabbit IHC 9
    Ab1-sox10 polyclonal Rabbit IHC 38
    Ab3-sox10 polyclonal IgG Rabbit IHC GeneTex
    13
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sox10
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-1.25sox10:GFP) sox10 GFP Danio rerio 1 4
    Tg(-4.7sox10:Cre) sox10 Cre Danio rerio 3 11
    Tg(-4.7sox10:GFP) sox10 GFP Danio rerio 3 15
    Tg(-4.9sox10:EGFP) sox10 EGFP Danio rerio 1 105
    Tg(-4.9sox10:Hsa.HIST1H2BJ-mCherry-2A-GLYPI-EGFP) sox10 2AEGFPGLYPImCherry Danio rerioHomo sapiens 1 3
    Tg(-4.9sox10:LY-GFP) sox10 GFPLY Danio rerio 1 3
    Tg(-4.9sox10:LY-Tomato) sox10 LYTomato Danio rerio 1 7
    Tg(-4.9sox10:mAGFP-gmnn-2A-mCherry-cdt1) sox10 2Acdt1gmnnmAGFPmCherry Danio rerio 1 1
    tg(-4.9sox10:nls-2a-gal4) sox10 2AGAL4NLS Danio rerio 1 1
    Tg(-5sox10:GAL4,UAS:Cre) sox10UAS CreGAL4 Danio rerio 1 3
    Tg(-7.2sox10:dnHsa.ERBB4-RFP,myl7:EGFP) myl7sox10 EGFPRFP Danio rerio 1 4
    Tg(-7.2sox10:EGFP) sox10 EGFP Danio rerio 1 23
    Tg(-7.2sox10:GAL4-VP16) sox10 GAL4 Danio rerio 1 4
    Tg(-7.2sox10:h2az2a-Eos) sox10 Eosh2az2a Danio rerio 1 1
    tg(-7.2sox10:ly-mcherry) sox10 LYmCherry Danio rerio 1 2
    Tg(-7.2sox10:MA-RFP) sox10 MARFP Danio rerio 1 3
    Tg(-4725sox10:EGFP) sox10 EGFP Danio rerio 1 6
    tg(sox10:cre,cryaa:dsred) cryaasox10 CreDsRed Danio rerio 1 1
    Tg(sox10:Cre,myl7:EGFP) myl7sox10 CreEGFP Danio rerio 1 2
    tg(sox10:cre-ert2) sox10 CreERT2 Danio rerio 1 1
    tg(sox10:cre-ert2,actb2:loxp-bfp-loxp-dsred) actb2sox10 BFPCreDsRedERT2LOXP Danio rerio 1 1
    Tg(sox10:Cre-ERT2,myl7:GFP) myl7sox10 CreERT2GFP Danio rerio 1 10
    Tg(sox10:DsRed) sox10 DsRed Danio rerio 1 10
    Tg(sox10:Eco.BirA-Hsa.HRAS-mCherry) sox10 mCherry Danio rerioEscherichia coli 2 2
    Tg(sox10:Eco.BirA-mCherry) sox10 mCherry Danio rerioEscherichia coli 0 1
    Tg(sox10:EGFP) sox10 EGFP Danio rerio 1 7
    Tg(sox10:EGFP-CAAX) sox10 CAAXEGFP Danio rerio 1 3
    Tg(sox10:EGFP-Hsa.HRAS) sox10 EGFP Danio rerioHomo sapiens 1 4
    Tg(sox10:Eos) sox10 Eos Danio rerio 1 9
    Tg(sox10:ERT2-Cre) sox10 CreERT2 Danio rerio 1 2
    Tg(sox10:GAL4-VP16) sox10 GAL4VP16 Danio rerio 1 6
    Tg(sox10:GAL4-VP16,myl7:Cerulean) myl7sox10 CeruleanGAL4VP16 Danio rerio 1 9
    Tg(sox10:GAL4-VP16-IRES-EGFP) sox10 EGFPGAL4VP16 Danio rerio 1 4
    Tg(sox10:Hsa.PDGFRA) sox10 Danio rerioHomo sapiens 1 1
    Tg(sox10:irf6_R84C,myl7:EGFP) myl7sox10 EGFPirf6 Danio rerio 1 3
    Tg(sox10:irf6_R84H,myl7:EGFP)) myl7sox10 EGFPirf6 Danio rerio 1 3
    Tg(sox10:irf6_R84K,myl7:EGFP) myl7sox10 EGFPirf6 Danio rerio 1 3
    Tg(sox10:Kaede) sox10 Kaede Danio rerio 1 13
    Tg(sox10:KALTA4,myl7:EGFP) myl7sox10 EGFPKALTA4 Danio rerio 1 2
    Tg(sox10:KikGR) sox10 KikGR Danio rerio 1 6
    Tg(sox10:LOXP-GFP-LOXP-Hsa.DLX3) sox10 GFP Danio rerioHomo sapiens 1 5
    Tg(sox10:mCherry) sox10 mCherry Danio rerio 1 7
    Tg(sox10:mCherry-CAAX) sox10 CAAXmCherry Danio rerio 1 2
    Tg(sox10:mir27b-EGFP) sox10 EGFPmir27b Danio rerio 1 1
    Tg(sox10:Mmu.Col4a5-MYC) sox10 MYC Danio rerioMus musculus 1 2
    Tg(sox10:mRFP) sox10 mRFP Danio rerio 1 88
    Tg(sox10:NLS-Eos) sox10 EosNLS Danio rerio 1 15
    Tg(sox10:plod3-mKate2) sox10 mKate2plod3 Danio rerio 1 2
    Tg(sox10:TagRFP) sox10 TagRFP Danio rerio 1 7
    Tg2(sox10:GAL4-VP16) sox10 GAL4VP16 Danio rerio 1 2
    Tg2(sox10:Hsa.PDGFRA) sox10 Danio rerioHomo sapiens 1 1
    Tg2(sox10:mCherry) sox10 mCherry Danio rerio 1 1
    Tg2(sox10:mRFP) sox10 mRFP Danio rerio 1 7
    tg3(sox10:mrfp) sox10 mRFP Danio rerio 1 1
    tg4(sox10:mrfp) sox10 mRFP Danio rerio 1 1
    tg5(sox10:mrfp) sox10 mRFP Danio rerio 1 1
    TgBAC(sox10:Eco.BirA-mCherry) sox10 mCherry Danio rerioEscherichia coli 1 2
    MARKER RELATIONSHIPS
    sox10 Contained in: [BAC] DKEY-201F15 (1) (order this)
    sox10 Encodes: [cDNA] MGC:100757 (1), MGC:195295 (1), MGC:195310 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131875 (1) 3231 nt
    Genomic GenBank:CU695115 (1) 47918 nt
    Select Tool
    Polypeptide UniProtKB:Q90XD1 (1) 485 aa
    Sequence Information (all 23)
    ORTHOLOGY for sox10 ( Chr: 3 )
    CITATIONS (343)