ZFIN ID: ZDB-GENE-011207-1
Gene Name: SRY (sex determining region Y)-box 10
Gene Symbol: sox10

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Previous Names: sox10b (1), cls, colorless (1), colourless, golas (1), gos (1), zgc:100757

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(Including Attributions)
Location: Chr: 3 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 196 figures from 126 publications
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Adult (90d-730d, breeding adult)
  anterior crista auditory epithelial support cell, brain oligodendrocyte, cranial ganglion, cranial neural crest (all 77) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
baz1 Point Mutation Unknown Unknown ENU
m241 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m618 Point Mutation Unknown Unknown ENU
    sox10_unspecified Unspecified Unknown Unknown
    t3 Insertion Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tw2 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tw11 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • utr13e1 Unknown Unknown Unknown
    Targeting reagents: CRISPR1-sox10 (1), CRISPR2-sox10 (1), MO1-sox10 (1), MO2-sox10 (1), MO3-sox10 (1) (all 6) expand
    PHENOTYPE
    Data: 51 figures from 24 publications
    Observed in: anterior crista hair cell, anterior crista, anterior macula, anterior semicircular canal (all 75) expand
    DISEASE ASSOCIATED WITH sox10 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Waardenburg's syndrome Waardenburg syndrome, type 2E, with or without neurologic involvement 611584
    Waardenburg syndrome, type 4C 613266
    PCWH syndrome 609136
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cranial skeletal system development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 22)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR009071 (1)
  • InterPro:IPR022151 (1)
  • PROSITE:PS50118 (1)
  • Pfam:PF00505 (1)
  • Pfam:PF12444 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA sox10-001 (1) 3205
    ncRNA sox10-002 (1) 2226
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIES
    Ab1-sox10 (1), Ab2-sox10 (1), Ab3-sox10 (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM sox10
    Tg(-1.25sox10:GFP), Tg(-4.7sox10:Cre), Tg(-4.7sox10:GFP), Tg(-4.9sox10:EGFP), Tg(-4.9sox10:LY-GFP) (all 40) expand
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    sox10Contained in: [BAC] DKEY-201F15 (1) (order this)
    sox10Encodes: [cDNA] MGC:100757 (1) (order this), MGC:195295 (1) (order this), MGC:195310 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131875 (1) 3231bp
    Genomic GenBank:CU695115 (1) 47918bp
    Select Tool
    Polypeptide UniProtKB:Q90XD1 (1) 485aa
    Sequence Clusters UniGene:83682 (1)
    Sequence Information (all 22)
    OTHER sox10 GENE PAGES
  • Gene:140616 (1)
  • VEGA:OTTDARG00000034423 (1)
  • Ensembl(GRCz10):ENSDARG00000077467 (1)
  • ORTHOLOGY for sox10 (Chr: 3)
    CITATIONS (271)