ZFIN ID: ZDB-GENE-011128-4
Gene Name: jagged canonical Notch ligand 1b
Gene Symbol: jag1b    Nomenclature History

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Previous Names: jag3, jagged1b, kmi (1), puc, unp1069

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have Notch binding activity. Involved in several processes, including animal organ development; face morphogenesis; and fin regeneration. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in Alagille syndrome; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Is expressed in several structures, including digestive system; endocrine system; nervous system; otic vesicle; and pharyngeal arch. Orthologous to human JAG1 (jagged canonical Notch ligand 1).
Genome Resources: Alliance (1),  Gene:140423 (1),  Ensembl(GRCz11):ENSDARG00000013168 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b1105 Point Mutation Unknown Premature Stop ENU
gd2Gt Transgenic Insertion Unknown Unknown DNA
  • China Zebrafish Resource Center (CZRC) (order this)
  • jj59 Point Mutation Donor Splice Site Frameshift ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018582Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018583Tg Transgenic Insertion Unknown Unknown DNA
    sa17080 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18567 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42247 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-jag1b N/A 12
    MO2-jag1b N/A 1
    MO3-jag1b N/A 3
    MO4-jag1b N/A 3
    MO5-jag1b N/A 1
    MO6-jag1b N/A 1
    MO7-jag1b N/A 1
    MO8-jag1b N/A 1
    DISEASE ASSOCIATED WITH jag1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Alagille syndrome Alliance Alagille syndrome 1 118450
    tetralogy of Fallot Alliance Tetralogy of Fallot 187500
    ?Deafness, congenital heart defects, and posterior embryotoxon 617992
    DISEASE ASSOCIATED WITH jag1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cartilage development involved in endochondral bone morphogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 24)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA jag1b-201 (1)    Ensembl 6754
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-jag1b polyclonal Rabbit 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM jag1b No data available
    MARKER RELATIONSHIPS
    jag1b Contained in: [BAC] CH211-159E5 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131863 (1) 6857 nt
    Genomic GenBank:CU138575 (1) 156198 nt
    Select Tool
    Polypeptide UniProtKB:A1A3Y7 (1) 1213 aa
    Sequence Information (all 12)
    ORTHOLOGY for jag1b ( Chr: 13 )
    CITATIONS (85)