Gene

jag1b

ID
ZDB-GENE-011128-4
Name
jagged canonical Notch ligand 1b
Symbol
jag1b Nomenclature History
Previous Names
  • jag3
  • jagged1b
  • kmi (1)
  • puc
  • unp1069
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to enable Notch binding activity. Acts upstream of or within several processes, including animal organ development; face morphogenesis; and fin regeneration. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including digestive system; endocrine system; nervous system; otic vesicle; and pharyngeal arch. Human ortholog(s) of this gene implicated in Alagille syndrome; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
33 figures from 29 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
18 figures from 9 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With jag1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Alagille syndrome Alliance Alagille syndrome 1 118450
tetralogy of Fallot Alliance Tetralogy of Fallot 187500
Charcot-Marie-Tooth disease, axonal, type 2HH 619574
?Deafness, congenital heart defects, and posterior embryotoxon 617992
Associated With jag1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR001007 VWFC domain
Domain IPR001774 Delta/Serrate/lag-2 (DSL) protein
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR011651 Notch ligand, N-terminal domain
Family IPR026219 Jagged/Serrate protein
Family IPR033108 Protein jagged-1
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Domain Details Per Protein
Protein Length Delta/Serrate/lag-2 (DSL) protein EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like, conserved site EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily Jagged/Serrate protein Notch ligand, N-terminal domain Protein jagged-1 VWFC domain
UniProtKB:Q90Y54 1213
UniProtKB:A1A3Y7 1213
UniProtKB:F1R986 1213
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-jag1b polyclonal Rabbit
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations