Gene

jag1a

ID
ZDB-GENE-011128-2
Name
jagged canonical Notch ligand 1a
Symbol
jag1a Nomenclature History
Previous Names
  • jag1
  • cb243 (1)
  • jagged1a (1)
  • sb:cb243
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have Notch binding activity. Involved in hematopoietic stem cell differentiation and thyroid gland development. Predicted to localize to integral component of membrane. Is expressed in several structures, including digestive system; lens placode; nervous system; neural keel; and neural tube. Human ortholog(s) of this gene implicated in Alagille syndrome; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1).
Genome Resources
Note
None
Expression
All Expression Data
18 figures from 13 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With jag1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Alagille syndrome Alliance Alagille syndrome 1 118450
tetralogy of Fallot Alliance Tetralogy of Fallot 187500
?Deafness, congenital heart defects, and posterior embryotoxon 617992
Associated With jag1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR001007 VWFC domain
Domain IPR001774 Delta/Serrate/lag-2 (DSL) protein
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR011651 Notch ligand, N-terminal domain
Family IPR026219 Jagged/Serrate protein
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Domain Details Per Protein
Protein Length Delta/Serrate/lag-2 (DSL) protein EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like, conserved site EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily Jagged/Serrate protein Notch ligand, N-terminal domain VWFC domain
UniProtKB:B3DGP3 1242
UniProtKB:Q90Y57 1242
UniProtKB:F1QP77 1242
UniProtKB:A1A3Y8 1242
UniProtKB:B8JKQ5 1253
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations