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ZIRC
ZFIN ID: ZDB-GENE-011128-2
Gene Name: jagged canonical Notch ligand 1a
Gene Symbol: jag1a    Nomenclature History

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Previous Names: jag1, cb243 (1), jagged1a (1), sb:cb243

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have Notch binding activity. Involved in hematopoietic stem cell differentiation and thyroid gland development. Predicted to localize to the plasma membrane. Human ortholog(s) of this gene implicated in Alagille syndrome; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Is expressed in several structures, including digestive system; lens placode; nervous system; neural keel; and neural tube. Orthologous to human JAG1 (jagged canonical Notch ligand 1).
Genome Resources: Alliance (1),  Gene:140421 (1),  Ensembl(GRCz11):ENSDARG00000030289 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011260Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028179Tg Transgenic Insertion Unknown Unknown DNA
    sa168 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1989 Point Mutation Unknown Splice Site ENU
    sa11248 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39691 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45084 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko992a Small Deletion Unknown Unknown CRISPR
    zko992b Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-jag1a 1
    MO1-jag1a N/A 3
    MO2-jag1a N/A 2
    MO3-jag1a N/A 1
    MO4-jag1a N/A 2
    DISEASE ASSOCIATED WITH jag1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Alagille syndrome Alliance Alagille syndrome 1 118450
    tetralogy of Fallot Alliance Tetralogy of Fallot 187500
    ?Deafness, congenital heart defects, and posterior embryotoxon 617992
    DISEASE ASSOCIATED WITH jag1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hematopoietic stem cell differentiation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 11)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA jag1a-202 (1)    Ensembl 6678
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM jag1a No data available
    MARKER RELATIONSHIPS
    jag1a Contained in: [BAC] DKEY-210M15 (1) (order this)
    jag1a Encodes: [EST] cb243 (1) (order this)
    [cDNA] MGC:193563 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131861 (1) 6669 bp
    Genomic GenBank:CU138540 (1) 163222 bp
    Select Tool
    Polypeptide UniProtKB:B8JKQ5 (1) 1253 aa
    Sequence Clusters UniGene:83677 (1)
    Sequence Information (all 25)
    ORTHOLOGY for jag1a ( Chr: 1 )
    CITATIONS (65)