ZFIN ID: ZDB-GENE-011128-2
Gene Name: jagged canonical Notch ligand 1a
Gene Symbol: jag1a
Sequence Ontology ID : SO:0000704

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Previous Names: jag1, cb243 (1), jagged1a (1), sb:cb243

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(Including Attributions)
Location: Chr: 1 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have Notch binding activity and calcium ion binding activity; involved in hematopoietic stem cell differentiation and thyroid gland development; predicted to localize to the integral  ...
GENE EXPRESSION
All Expression Data: 16 figures from 11 publications
Directly Submitted Expression Data: 6 figures (16 images) from Thisse et al., 2001 [cb243]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011260Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028179Tg Transgenic Insertion Unknown Unknown DNA
    sa168 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1989 Point Mutation Unknown Splice Site ENU
    sa11248 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39691 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45084 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko992a Small Deletion Unknown Unknown CRISPR
    zko992b Small Deletion Unknown Unknown CRISPR
    Targeting reagents:
    PHENOTYPE
    Data: 3 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH jag1a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Alagille syndrome Alagille syndrome 1 118450
    tetralogy of Fallot Tetralogy of Fallot 187500
    ?Deafness, congenital heart defects, and posterior embryotoxon 617992
    ?Deafness, congenital heart defects, and posterior embryotoxon 617992
    DISEASE ASSOCIATED WITH jag1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hematopoietic stem cell differentiation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000152 (1)
  • InterPro:IPR000742 (1)
  • InterPro:IPR001007 (1)
  • InterPro:IPR001774 (1)
  • InterPro:IPR001881 (1)
  • InterPro:IPR009030 (1)
  • InterPro:IPR011651 (1)
  • InterPro:IPR013032 (1)
  • InterPro:IPR018097 (1)
  • InterPro:IPR026219 (1)
  • PROSITE:PS00010 (1)
  • PROSITE:PS00022 (1)
  • PROSITE:PS01186 (1)
  • PROSITE:PS01187 (1)
  • PROSITE:PS50026 (1)
  • PROSITE:PS51051 (1)
  • Pfam:PF00008 (1)
  • Pfam:PF01414 (1)
  • Pfam:PF07657 (1)
  • Pfam:PF12661 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA jag1a-202 (1) 6678
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM jag1a No data available
    MARKER RELATIONSHIPS
    jag1aContained in: [BAC] DKEY-210M15 (1) (order this)
    jag1aEncodes: [EST] cb243 (1) (order this)
    [cDNA] MGC:193563 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131861 (1) 6669bp
    Genomic GenBank:CU138540 (1) 163222bp
    Select Tool
    Polypeptide UniProtKB:B8JKQ5 (1) 1253aa
    Sequence Clusters UniGene:83677 (1)
    Sequence Information (all 25)
    OTHER jag1a GENE PAGES
  • Alliance (1)
  • Gene:140421 (1)
  • VEGA:OTTDARG00000027091 (1)
  • Ensembl(GRCz11):ENSDARG00000030289 (2)
  • ORTHOLOGY for jag1a (Chr: 1)
    CITATIONS (64)