ZFIN ID: ZDB-GENE-011105-1
Gene Name: protein kinase C, iota
Gene Symbol: prkci    Nomenclature History

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Previous Names: aPKC[l] (1), has (1), heart and soul

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have phospholipid binding activity and protein serine/threonine kinase activity. Involved in several processes, including animal organ development; digestive tract development; and morphogenesis of an epithelium. Localizes to intrinsic component of plasma membrane and zonula adherens. Is expressed in several structures, including blastoderm; common cardinal vein; eye; posterior lateral line primordium; and pronephric duct. Orthologous to human PRKCI (protein kinase C iota).
Genome Resources: Alliance (1),  Gene:117507 (1),  Ensembl(GRCz11):ENSDARG00000021225 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi3208Tg Transgenic Insertion Exon 11 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m129 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m567 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m781 Unknown Unknown Unknown ENU
    sa14108 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17535 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-prkci N/A 18
    MO2-prkci N/A 2
    MO3-prkci N/A 2
    DISEASE ASSOCIATED WITH prkci HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH prkci VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell projection assembly (more)
    Cellular Component intrinsic component of plasma membrane (more)
    Molecular Function phospholipid binding (more)
    GO Terms (all 45)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA prkci-201 (1)    Ensembl 3550
    ncRNA prkci-002 (1)    Ensembl 368
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-prkcz polyclonal IgG Rabbit IHC, WB Santa Cruz Biotechnology, Inc.
    80
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM prkci
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:mKate2-prkci-CAAX) hsp70l CAAXmKate2prkci Danio rerio 1 1
    Tg(myl7:prkci) myl7 prkci Danio rerio 1 5
    Tg1(5xUAS:mir30e-2-shRNAprkci,Tomato) UAS mir30e-2prkciTomato Danio rerio 1 2
    Tg2(5xUAS:mir30e-2-shRNAprkci,Tomato) UAS mir30e-2prkciTomato Danio rerio 1 2
    MARKER RELATIONSHIPS
    prkci Contained in: [BAC] DKEY-31B10 (1) (order this)
    prkci Encodes: [EST] eu720 (1)
    [cDNA] MGC:55201 (1), MGC:86563 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131855 (1) 3528 nt
    Genomic GenBank:BX511231 (1) 93016 nt
    Select Tool
    Polypeptide UniProtKB:Q6DI53 (1) 588 aa
    Sequence Information (all 19)
    ORTHOLOGY for prkci ( Chr: 2 )
    CITATIONS (94)