Gene

ugdh

ID
ZDB-GENE-011022-1
Name
UDP-glucose 6-dehydrogenase
Symbol
ugdh Nomenclature History
Previous Names
  • ik:tdsubc_2a8 (1)
  • jek
  • jekyll
  • sb:eu659
  • tdsubc_2a8
  • xx:tdsubc_2a8
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have NAD binding activity and UDP-glucose 6-dehydrogenase activity. Involved in atrioventricular valve formation; determination of left/right symmetry; and positive regulation of signal transduction. Predicted to localize to cytosol and nucleus. Is expressed in several structures, including axis; head; heart tube; mesoderm; and vestibuloauditory system. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy. Orthologous to human UGDH (UDP-glucose 6-dehydrogenase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
23 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ugdh Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
developmental and epileptic encephalopathy 84 Alliance Developmental and epileptic encephalopathy 84 618792
Associated With ugdh Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal
Domain IPR014026 UDP-glucose/GDP-mannose dehydrogenase, dimerisation
Domain IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal
Family IPR017476 UDP-glucose/GDP-mannose dehydrogenase
Family IPR028356 UDP-glucose 6-dehydrogenase, eukaryotic type
Homologous_superfamily IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
Homologous_superfamily IPR036220 UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily NAD(P)-binding domain superfamily UDP-glucose 6-dehydrogenase, eukaryotic type UDP-glucose/GDP-mannose dehydrogenase UDP-glucose/GDP-mannose dehydrogenase, C-terminal UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily UDP-glucose/GDP-mannose dehydrogenase, dimerisation UDP-glucose/GDP-mannose dehydrogenase, N-terminal
UniProtKB:A8WGP7 493
UniProtKB:B3DJ97 493
UniProtKB:Q90XP7 493
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations