ZFIN ID: ZDB-GENE-010724-18
Gene Name: apolipoprotein Ea
Gene Symbol: apoea    Nomenclature History

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Previous Names: ApoE-1 (1), im:7036787, wu:fb69a05, zgc:110064

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have several functions, including cholesterol binding activity; cholesterol transfer activity; and phosphatidylcholine-sterol O-acyltransferase activator activity. Predicted to be involved in several processes, including lipid homeostasis; lipid transport; and plasma lipoprotein particle organization. Predicted to localize to the chylomicron and high-density lipoprotein particle. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); familial hyperlipidemia (multiple); and neurodegenerative disease (multiple). Is expressed in brain; female organism; male organism; and yolk syncytial layer. Orthologous to human APOE (apolipoprotein E).
Genome Resources: Alliance (1),  Gene:553587 (1),  Ensembl(GRCz11):ENSDARG00000102004 (1)
GENE EXPRESSION
All Expression Data: 12 figures from 5 publications
Directly Submitted Expression Data: 6 figures (5 images) from Thisse et al., 2004 [MGC:110064]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa36796 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-apoea
    4
    TALEN1-apoea
    1
    TALEN2-apoea
    1
    TALEN3-apoea
    1
    TALEN4-apoea
    1
    TALEN5-apoea
    1
    TALEN6-apoea
    2
    PHENOTYPE
    Data: Fig. S4 from Hwang et al., 2013
    Observed in:
    DISEASE ASSOCIATED WITH apoea HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    age related macular degeneration 1 Alliance {?Macular degeneration, age-related} 603075
    Alzheimer's disease 2 Alliance Alzheimer disease 2 104310
    Alzheimer's disease 3 Alliance {?Alzheimer disease, protection against, due to APOE3-Christchurch} 607822
    hyperlipoproteinemia type III Alliance Hyperlipoproteinemia, type III 617347
    {Coronary artery disease, severe, susceptibility to} 617347
    sea-blue histiocytosis Alliance Sea-blue histiocyte disease 269600
    Lipoprotein glomerulopathy 611771
    DISEASE ASSOCIATED WITH apoea VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process lipid transport (more)
    Cellular Component extracellular region (more)
    Molecular Function lipid binding (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000074 Apolipoprotein A/E
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA apoea-201 (1)    Ensembl 781
    apoea-202 (1)    Ensembl 1065
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM apoea No data available
    MARKER RELATIONSHIPS
    apoea Contained in: [BAC] CH73-347E22 (1)
    apoea Contains: [SNP] rs3728965 (1), rs3728966 (1), rs3728967 (1), rs3728968 (1)
    apoea Encodes: [EST] fb69a05 (1), IMAGE:7036787
    [cDNA] MGC:110064 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001020565 (1) 1086 bp
    Genomic GenBank:CU855694 (1) 104180 bp
    Select Tool
    Polypeptide UniProtKB:Q503V2 (1) 269 aa
    Sequence Information (all 12)
    ORTHOLOGY for apoea ( Chr: 19 )
    CITATIONS (48)