ZFIN ID: ZDB-GENE-010614-1
Gene Name: chemokine (C-X-C motif), receptor 4b
Gene Symbol: cxcr4b    Nomenclature History

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Previous Names: drCXCR4b1 (1), cb403 (1), ody, odysseus, zgc:109863

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Exhibits G protein-coupled chemoattractant receptor activity. Involved in several processes, including gamete generation; nervous system development; and regulation of chemotaxis. Localizes to the plasma membrane. Human ortholog(s) of this gene implicated in WHIM syndrome; hematologic cancer (multiple); leukopenia; osteoporosis; and pancreatic adenocarcinoma. Is expressed in several structures, including anterior neural keel; immature eye; mesoderm; nervous system; and neurogenic placode. Orthologous to human CXCR4 (C-X-C motif chemokine receptor 4).
Genome Resources: Alliance (1),  Gene:114447 (1),  Ensembl(GRCz11):ENSDARG00000041959 (2)
GENE EXPRESSION
All Expression Data: 102 figures from 73 publications
Directly Submitted Expression Data: 6 figures (56 images) from Thisse et al., 2001 [cb403]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ioz106 Small Deletion Unknown Unknown CRISPR
t26035 Point Mutation Unknown Premature Stop
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cxcr4b
    1
    CRISPR2-cxcr4b 1
    MO1-cxcr4b N/A 13
    MO2-cxcr4b N/A 5
    MO3-cxcr4b N/A 6
    MO4-cxcr4b N/A 1
    MO5-cxcr4b N/A 2
    MO6-cxcr4b N/A 3
    MO7-cxcr4b N/A 2
    MO8-cxcr4b N/A 1
    DISEASE ASSOCIATED WITH cxcr4b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    WHIM syndrome Alliance WHIM syndrome 193670
    Myelokathexis, isolated
    DISEASE ASSOCIATED WITH cxcr4b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of axon extension (more)
    Cellular Component plasma membrane (more)
    Molecular Function G protein-coupled chemoattractant receptor activity (more)
    GO Terms (all 39)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR017452 GPCR, rhodopsin-like, 7TM
    Family IPR000276 G protein-coupled receptor, rhodopsin-like
    Family IPR000355 Chemokine receptor family
    Family IPR001277 CXC chemokine receptor 4/atypical chemokine receptor 2
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cxcr4b-201 (1)    Ensembl 1674
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-cxcr4b monoclonal Mouse 1
    CONSTRUCTS WITH SEQUENCES FROM cxcr4b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-8mpx:cxcr4b-EGFP) mpx cxcr4bEGFP Danio rerio 1 2
    Tg(cxcr4b:cxcr4b-LIFEACT-Citrine,cryaa:DsRed) cryaacxcr4b Citrinecxcr4bDsRedLIFEACT Danio rerio 1 1
    Tg(cxcr4b:LIFEACT-RFP) cxcr4b RFP Danio rerio 1 3
    Tg(cxcr4b:mRFP) cxcr4b mRFP Danio rerio 1 9
    Tg1(-8mpx:cxcr4b-EGFP) mpx cxcr4bEGFP Danio rerio 1 8
    TgBAC(cxcr4b-:h2az2a-GFP) cxcr4b GFPh2az2a Danio rerio 0 1
    tgbac(cxcr4b:cxcr4a) cxcr4b cxcr4a Danio rerio 1 1
    TgBAC(cxcr4b:cxcr4b-EGFP-IRES-mKate2-CAAX,cryaa:DsRed) cryaacxcr4b DsRedEGFPmKate2 Danio rerio 2 6
    TgBAC(cxcr4b:cxcr4b-GFP) cxcr4b cxcr4bGFP Danio rerio 1 4
    TgBAC(cxcr4b:cxcr4b-mKate2-IRES-EGFP-CAAX,cryaa:DsRed) cryaacxcr4b DsRedEGFPmKate2 Danio rerio 1 6
    TgBAC(cxcr4b:cxcr4b-mKate2-sfGFP) cxcr4b cxcr4bGFPmKate2 Danio rerio 1 1
    TgBAC(cxcr4b:cxcr4b-TagRFP) cxcr4b cxcr4bTagRFP Danio rerio 1 1
    TgBAC(cxcr4b:cxcr4b-TagRFP-sfGFP,crybb1:ECFP) crybb1cxcr4b ECFPGFPTagRFP Danio rerio 1 6
    TgBAC(cxcr4b:cxcr4b-Tomato-sfGFP) cxcr4b cxcr4bGFPTomato Danio rerio 1 1
    TgBAC(cxcr4b:GAL4-VP16) cxcr4b GAL4VP16 Danio rerio 1 1
    TgBAC(cxcr4b:h2az2a-GFP,cryaa:DsRed) cryaacxcr4b DsRedGFPh2az2a Danio rerio 1 4
    TgBAC(cxcr4b:h2az2a-mCherry,cryaa:DsRed) cryaacxcr4b DsRedh2az2amCherry Danio rerio 1 2
    tgbac(cxcr4b:hsa.hist1h2bj-rfp) cxcr4b RFP Danio rerioHomo sapiens 1 1
    TgBAC(cxcr4b:LEXPR,cryaa:CFP) cryaacxcr4b CFPLEXPR Danio rerio 1 1
    TgBAC(cxcr4b:LEXPR,LEXOP:LY-RFP,cryaa:CFP) cryaacxcr4bLEXOP CFPLEXPRLYRFP Danio rerio 1 1
    TgBAC(cxcr4b:LY-TagRFP-sfGFP,crybb1:ECFP) crybb1cxcr4b ECFPGFPTagRFP Danio rerio 1 4
    TgBAC(cxcr4b:NLS-Tomato) cxcr4b cxcr4bTomato Danio rerio 1 7
    tgbac(cxcr4b:zgrad-ires-2a-tagbfp,myl7:mscarlet) cxcr4bmyl7 mScarlet2AIRESTagBFPzGRAD Danio rerio 1 2
    MARKER RELATIONSHIPS
    cxcr4b Contained in: [Fosmid] CH1073-406F3 (1)
    cxcr4b Encodes: [EST] cb403 (1)
    [cDNA] MGC:109863 (1), MGC:192953 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131834 (1) 1651 nt
    Genomic GenBank:CU694482 (1) 35104 nt
    Select Tool
    Polypeptide UniProtKB:Q504H4 (1) 353 aa
    Sequence Information (all 19)
    ORTHOLOGY for cxcr4b ( Chr: 9 )
    CITATIONS (198)