Gene

cxcr4b

ID
ZDB-GENE-010614-1
Name
chemokine (C-X-C motif), receptor 4b
Symbol
cxcr4b Nomenclature History
Previous Names
  • drCXCR4b1 (1)
  • cb403 (1)
  • ody
  • odysseus
  • zgc:109863
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Exhibits G protein-coupled chemoattractant receptor activity. Involved in several processes, including gamete generation; nervous system development; and regulation of chemotaxis. Localizes to plasma membrane. Is expressed in several structures, including anterior neural keel; immature eye; mesoderm; nervous system; and neurogenic placode. Human ortholog(s) of this gene implicated in WHIM syndrome; hematologic cancer (multiple); leukopenia; osteoporosis; and pancreatic adenocarcinoma. Orthologous to human CXCR4 (C-X-C motif chemokine receptor 4).
Genome Resources
Note
None
Expression
All Expression Data
108 figures from 77 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
25 figures from 18 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cxcr4b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
WHIM syndrome Alliance WHIM syndrome 193670
Myelokathexis, isolated
Associated With cxcr4b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR000355 Chemokine receptor family
Family IPR001277 CXC chemokine receptor 4/atypical chemokine receptor 2
Domain Details Per Protein
Protein Length Chemokine receptor family CXC chemokine receptor 4/atypical chemokine receptor 2 GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like
UniProtKB:Q9PTF7 353
UniProtKB:Q504H4 353
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cxcr4b monoclonal Mouse
1
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations