Gene

vars1

ID
ZDB-GENE-010601-1
Name
valyl-tRNA synthetase 1
Symbol
vars1 Nomenclature History
Previous Names
  • vars2 (1)
  • vars
  • CHUNP6879
  • im:7137378
  • wu:fb07a11 (1)
  • wu:fb07d10 (1)
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have valine-tRNA ligase activity. Predicted to be involved in valyl-tRNA aminoacylation. Predicted to localize to cytosol. Is expressed in digestive system; immature eye; intermediate cell mass of mesoderm; nervous system; and somite. Orthologous to human VARS1 (valyl-tRNA synthetase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With vars1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Neurodevelopmental disorder with microcephaly, seizures, and cortical atrophy 617802
Associated With vars1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
Domain IPR002300 Aminoacyl-tRNA synthetase, class Ia
Domain IPR004046 Glutathione S-transferase, C-terminal
Domain IPR010987 Glutathione S-transferase, C-terminal-like
Domain IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
Domain IPR033705 Valyl tRNA synthetase, anticodon-binding domain
Family IPR002303 Valine-tRNA ligase
Homologous_superfamily IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
Homologous_superfamily IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
Homologous_superfamily IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Homologous_superfamily IPR036282 Glutathione S-transferase, C-terminal domain superfamily
Homologous_superfamily IPR037118 Valyl-tRNA synthetase, tRNA-binding arm superfamily
Domain Details Per Protein
Protein Length Aminoacyl-tRNA synthetase, class Ia Aminoacyl-tRNA synthetase, class Ia, anticodon-binding Aminoacyl-tRNA synthetase, class I, conserved site Glutathione S-transferase, C-terminal Glutathione S-transferase, C-terminal domain superfamily Glutathione S-transferase, C-terminal-like Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding Rossmann-like alpha/beta/alpha sandwich fold Valine-tRNA ligase Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain Valyl tRNA synthetase, anticodon-binding domain Valyl-tRNA synthetase, tRNA-binding arm superfamily
UniProtKB:Q8JHH7 425
UniProtKB:F1Q740 1271
UniProtKB:Q9IAB3 107
UniProtKB:Q5BLI2 700
UniProtKB:Q8JHH6 505
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations