ZFIN ID: ZDB-GENE-010525-1
Gene Name: solute carrier family 4 member 1a (Diego blood group)
Gene Symbol: slc4a1a    Nomenclature History

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Previous Names: slc4a1, zAE1a (1), AE1/band 3 (1), band3 (1), erythroid anion exchanger 1 (1), ret, retsina, si:dz180g5.1, zgc:111889, zgc:152771

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have inorganic anion exchanger activity. Involved in anion transport; embryonic hemopoiesis; and erythrocyte differentiation. Predicted to localize to integral component of membrane. Is expressed in several structures, including erythroid lineage cell; hematopoietic system; liver; mesoderm; and pleuroperitoneal region. Used to study cardiomyopathy. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; hereditary spherocytosis; hereditary spherocytosis type 4; malaria; and renal tubular acidosis. Orthologous to human SLC4A1 (solute carrier family 4 member 1 (Diego blood group)).
Genome Resources: Alliance (1),  Gene:84703 (1),  Ensembl(GRCz11):ENSDARG00000012881 (2)
DISEASE ASSOCIATED WITH slc4a1a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary spherocytosis type 4 Alliance Spherocytosis, type 4 612653
Cryohydrocytosis 185020
Ovalocytosis, SA type 166900
Renal tubular acidosis, distal, AD 179800
Renal tubular acidosis, distal, AR 611590
[Blood group, Diego] 110500
[Blood group, Froese] 601551
[Blood group, Swann] 601550
[Blood group, Waldner] 112010
[Blood group, Wright] 112050
[Malaria, resistance to] 611162
DISEASE ASSOCIATED WITH slc4a1a VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
cardiomyopathy slc4a1atr265/tr265 standard conditions Ding et al., 2016
GENE ONTOLOGY
Ontology GO Term
Biological Process anion transport (more)
Cellular Component integral component of membrane (more)
Molecular Function protein binding (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ottdart00000001986 (1) 3500
slc4a1a-203 (1)    Ensembl 3554
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab2-slc4a1 polyclonal Rabbit 1
Ab1-slc4a1 polyclonal Rabbit 1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM slc4a1a No data available
MARKER RELATIONSHIPS
slc4a1a Contained in: [BAC] DKEY-15K2 (1) (order this)
[PAC] BUSM1-180G5
slc4a1a Encodes: [EST] IMAGE:7145604 (1), IMAGE:7158110 (1)
[cDNA] MGC:111889, MGC:152771 (1), MGC:195366 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_198338 (1) 3478 nt
Genomic GenBank:AL604064 (1) 136041 nt
Select Tool
Polypeptide UniProtKB:B3DKQ1 (1) 905 aa
Sequence Information (all 36)
ORTHOLOGY for slc4a1a ( Chr: 3 )
CITATIONS (76)