ZFIN ID: ZDB-GENE-010403-1
Gene Name: cone-rod homeobox
Gene Symbol: crx
Sequence Ontology ID : SO:0000704

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(Including Attributions)
Location: Chr: 5 Mapping Details/Browsers
AUTOMATED DESCRIPTION
Exhibits DNA binding activity; involved in eye photoreceptor cell development, negative regulation of retinal cell programmed cell death, and visual perception; predicted to localize to the nucleus;  ...
GENE EXPRESSION
All Expression Data: 61 figures from 35 publications
Directly Submitted Expression Data: 6 figures (10 images) from Thisse et al., 2005 [eu68]
  7 figures (7 images) from Thisse et al., 2005 [eu16]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Targeting reagents:
PHENOTYPE
Data: 5 figures from 5 publications
Observed in:
DISEASE ASSOCIATED WITH crx HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
cone-rod dystrophy 2 Cone-rod retinal dystrophy-2 120970
Leber congenital amaurosis 7 Leber congenital amaurosis 7 613829
DISEASE ASSOCIATED WITH crx VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process eye development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR003025 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR013851 (1)
  • InterPro:IPR017970 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • Pfam:PF03529 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA crx-201 (1) 2381
    antisense ottdart00000059965 (1) 825
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM crx
    MARKER RELATIONSHIPS
    crxContained in: [BAC] CH211-46E8 (1) (order this)
    crxEncodes: [EST] eu16 (1), eu68 (1)
    [cDNA] MGC:73334 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_152940 (1) 2385bp
    Genomic GenBank:BX927323 119560bp
    Select Tool
    Polypeptide UniProtKB:Q8JIZ3 (1) 281aa
    Sequence Clusters UniGene:14325 (1)
    Sequence Information (all 14)
    OTHER crx GENE PAGES
  • Alliance (1)
  • Gene:81881 (1)
  • VEGA:OTTDARG00000035239 (1)
  • VEGA:OTTDARG00000041592 (1)
  • ORTHOLOGY for crx (Chr: 5)
    CITATIONS (92)