Gene

crx

ID
ZDB-GENE-010403-1
Name
cone-rod homeobox
Symbol
crx Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Exhibits DNA binding activity. Involved in eye photoreceptor cell development; negative regulation of retinal cell programmed cell death; and visual perception. Predicted to localize to nucleus. Is expressed in immature eye; neuroepithelial cell; photoreceptor cell; pineal complex; and visual system. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 7 and cone-rod dystrophy 2. Orthologous to several human genes including CRX (cone-rod homeobox).
Genome Resources
Note
None
Expression
All Expression Data
62 figures from 36 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With crx Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cone-rod dystrophy 2 Alliance Cone-rod retinal dystrophy-2 120970
Leber congenital amaurosis 7 Alliance Leber congenital amaurosis 7 613829
Associated With crx Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR013851 Transcription factor Otx, C-terminal
Family IPR003025 Transcription factor Otx
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox-like domain superfamily Transcription factor Otx Transcription factor Otx, C-terminal
UniProtKB:Q8JIZ3 281
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-crx polyclonal Rabbit
  • IHC
Research Genetics, Inc.
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations