ZFIN ID: ZDB-GENE-010403-1
Gene Name: cone-rod homeobox
Gene Symbol: crx    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Exhibits DNA binding activity. Involved in eye photoreceptor cell development; negative regulation of retinal cell programmed cell death; and visual perception. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 7 and cone-rod dystrophy 2. Is expressed in immature eye; neuroepithelial cell; photoreceptor cell; pineal complex; and visual system. Orthologous to several human genes including CRX (cone-rod homeobox).
Genome Resources: Alliance (1),  Gene:81881 (1),  Ensembl(GRCz11):ENSDARG00000011989 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-crx N/A 5
MO2-crx N/A 1
MO3-crx N/A 7
DISEASE ASSOCIATED WITH crx HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cone-rod dystrophy 2 Alliance Cone-rod retinal dystrophy-2 120970
Leber congenital amaurosis 7 Alliance Leber congenital amaurosis 7 613829
DISEASE ASSOCIATED WITH crx VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process eye development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
antisense ottdart00000059965 (1) 825
mRNA crx-201 (1)    Ensembl 2381
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-crx polyclonal Rabbit IHC Research Genetics, Inc.
3
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM crx
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(crx:MA-CFP) crx CFP Danio rerio 1 13
Tg(crx:MA-YFP-2A-thrb) crx thrbYFP Danio rerio 0 3
Tg(crx:MA-YFP-2A-thrb,myl7:EGFP) crxmyl7 2AEGFPMAthrbYFP Danio rerio 1 4
Tg(crx:man2a1-GFP) crx GFPman2a1 Danio rerio 1 5
MARKER RELATIONSHIPS
crx Contained in: [BAC] CH211-46E8 (1)
crx Encodes: [EST] eu16 (1), eu68 (1)
[cDNA] MGC:73334 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_152940 (1) 2385 nt
Genomic GenBank:BX927323 119560 nt
Select Tool
Polypeptide UniProtKB:Q8JIZ3 (1) 281 aa
Sequence Information (all 13)
ORTHOLOGY for crx ( Chr: 5 )
CITATIONS (99)